Ali Twelvetrees

363 Followers
412 Following
108 Posts
Sir Henry Dale Fellow | cell & molecular neurobiology | kinesin, dynein, slow transport and neurodegeneration | preferably one molecule at a time | my opinions | she/her
Websitehttps://www.twelvetreeslab.co.uk
ResearchCell & Molecular Neurobiology
LocationSheffield, UK

Welp. That's a big change.

NIH cuts indirect costs to 15%. (Big change from the typical indirect costs paid to universities that are in the 50% range.)

I wonder if this will apply to private businesses as well, many of whom had previously negotiated much higher indirect costs. (I've seen 80% and even 100% before.)

https://arstechnica.com/science/2025/02/new-nih-policy-will-slash-support-money-to-research-universities/

National Institutes of Health radically cuts support to universities

Sudden and drastic change will make it hard for researchers to keep the lights on.

Ars Technica
@jgpausas @Psy_Fer_ @Mastodon @rstats @ecology @plants @botany @plantscience @nature @biodiversity @evolution I don’t work on phylo trees, but I know ggtree for R is out there which would be my starting point

Want to help preserve data and information that's being removed from US government websites? Got a spare computer and some bandwidth?

Run an instance of the Archive Team Warrior VM and you'll contribute to the distributed downloading and preservation of stuff to the Internet Archive:

https://www.reddit.com/r/DataHoarder/comments/1ihalfe/how_you_can_help_archive_us_government_data_right/

It's (relatively) simple to get up and running, and you don't need to have a ton of your own storage space to contribute.

#downloadTheGovernment #uspol

Time to re-hang the winter solstice Writhing Wreathing

#AlgorithmicArt #CreativeCoding #Processing

What does it mean for something to be Turing complete?

I answer this question, and more, through a series of fully interactive Turing machine simulations! Play, pause, step forwards and backwards, and even write your own Turing machine programs in my latest blog post.

https://samwho.dev/turing-machines

Turing Machines

An interactive introduction to Turing machines, the theoretical foundation of modern computing.

Our preprint is up! Take a look if you like kinesin, microtubule transport, single molecule FRET or biophysics. It’s a bit of shift to how we’ve been used to thinking about kinesin-1 regulation as we try to get a handle on its conformational dynamics. Super proud of to have this milestone out in the world and all the hard work it represents from everyone involved.
#kinesin #microtubules #biophys #smFRET #SingleMolecule #AxonalTransport https://biologists.social/@TwelvetreesLab/113691748206473977
Twelvetrees Lab (@[email protected])

Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo http://biorxiv.org/cgi/content/short/2024.12.20.629623v1?rss=1

biologists.social
Last act of the year was to submit the lab’s first proper manuscript to bioRxiv. Thank you to all the preprint elves screening manuscripts right now! So relieved it’s almost out in the world 🎉
@xtaldave @TwelvetreesLab Oooh - sounds useful!! I can’t get over how simple it will be to do things that were previously out of reach for our proteins.
Christmas has come early! A shiny new mass photometer from Refeyn - so much potential waiting to be unleashed ✨✨
@CellySally @Co_Biologists Ha no worries - preaching to the converted. Just need a more biophysics one for the next paper…