does anyone have recs for a good vet for cats in SF? we've tried 4 in the last year and they are all massively overworked and under responsive and totally unhelpful when we need emergency care!!

bonus points if they do home visits since our new babies are very scared!

so for folks with plasmids that Addgene won't distribute - how do you handle distribution? Do you have to execute a fresh MTA with the company of origin and the new party?

(paging @JoachimGoedhart because I think you ran into these issues for mTurq2?)

Hey everyone, Happy Holidays! I come bearing the gift of our last preprint of 2022.

https://www.biorxiv.org/content/10.1101/2022.12.26.521943v1

Will probably run a legit "Toot-orial" in the New Year when people are back, but briefly: We have long been interested in how the genome is packaged in sperm, both as a cool chromatin state and also because several labs have reported that mutations that affect histone modifications in the testis have intergenerational effects. 1/n

What is the best name for the stuffed animal pictured in the reply?

(Please boost for reach)

After a long busy stretch and a few offline days is #introduction time!

I'm a molecular biologist in love with #development and everything #omics and #bioinformatics. I try to understand how transcription is kickstarted in early embryogenesis during the activation of the zygotic genome

I'm a co-organiser of the #FragileNucleosome seminar series with a few other great folks also here @chrstn_e @BenMartin @generegulation @XiaoliWu

Happy to finally explore around! :)

Huh, another chicken to human comparative (I think this should be spelled comparitive -- like compar*I*son -- but whatever) genomics effort out today: this one on chromosome folding:

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01731-4

Our new preprint! Nucleosome repositioning in chronic lymphocytic leukaemia (CLL) https://www.biorxiv.org/content/10.1101/2022.12.20.518743v1
▶️Nucleosome changes at cancer-sensitive regions allow patient stratification
▶️Nucleosome repeat length (NRL) decreases with #cancer aggressiveness
▶️Interplay with #methylation, #TFbinding and more!

#CLL, #nucleosome, #leukaemia, #chromatin