📰 "The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5"
https://pubmed.ncbi.nlm.nih.gov/39615799/ #Microtubule
The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5 - PubMed
The autosomal recessive disease ataxia-telangiectasia (A-T) presents with cerebellar degeneration, immunodeficiency, radiosensitivity, capillary dilatations, and pulmonary infections. Most symptoms outside the nervous system can be explained by failures of the disease protein ATM as a Ser/Thr-kinase …
📰 "Targeting cytoskeletal biomechanics to modulate airway smooth muscle contraction in asthma"
https://pubmed.ncbi.nlm.nih.gov/39615690/ #CytoskeletonTargeting cytoskeletal biomechanics to modulate airway smooth muscle contraction in asthma - PubMed
To contract, to deform, and remodel, the airway smooth muscle (ASM) cell relies on dynamic changes in the structure of its mechanical force-bearing cytoskeleton. These alternate between a "fluid-like" (relaxed) state characterized by weak contractile protein-protein interactions within the cytoskele …
📰 "Phosphorylation of Lamin A/C regulates structural integrity of the nuclear envelope"
https://pubmed.ncbi.nlm.nih.gov/39615679/ #LaminPhosphorylation of Lamin A/C regulates structural integrity of the nuclear envelope - PubMed
Dynamic disassembly and reconstruction of the nuclear lamina during entry and exit of mitosis, respectively, are pivotal steps in proliferation of higher eukaryotic cells. Although numerous post-translational modifications of lamin proteins have been identified, key factors driving the nuclear lamin …
📰 "Engineered Recombinant Hagfish Intermediate Filament Proteins: Unraveling Domain Roles in Synthetic Fiber Formation and Mechanics"
https://pubmed.ncbi.nlm.nih.gov/39619506/ #IntermediateFilamentEngineered Recombinant Hagfish Intermediate Filament Proteins: Unraveling Domain Roles in Synthetic Fiber Formation and Mechanics - PubMed
Hagfish intermediate filament (HIF) proteins, consisting of α and γ subunits, have been previously recombinantly expressed, purified, and utilized to form dry fibers with impressive mechanical properties. HIFα and HIFγ consist of three protein domains (N-termini, C-termini, and central rod domain). …
📰 "Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice"
https://pubmed.ncbi.nlm.nih.gov/39619139/ #LaminNon-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice - PubMed
The truncating mutations of <i>LMNA</i> are the major causes of cardiomyopathy. Here we studied 3 mouse models that carry germline, cardiomyocyte-specific, or genetic mosaic <i>Lmna</i> truncating mutations. Whereas the germline mutant manifested cardiac maturation defects, cardiomyocyte-specific mu …
📰 "ABHD1 Facilitates Intermediate Filament-Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy"
https://pubmed.ncbi.nlm.nih.gov/39619568/ #IntermediateFilamentABHD1 Facilitates Intermediate Filament-Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy - PubMed
Diabetic retinopathy (DR) is one of the most common complications of diabetes and induces severe visual impairment worldwide. Endothelial cell dysfunction plays an important role in the pathogenesis of DR. Here, we keep a watchful eye on <i>α</i>/<i>β</i>-hydrolase domain-containing 1 (ABHD1), a pot …
📰 "A Method for Analyzing Acentrosomal Mitotic Spindles in Human Cells"
https://pubmed.ncbi.nlm.nih.gov/39616579/ #MicrotubuleA Method for Analyzing Acentrosomal Mitotic Spindles in Human Cells - PubMed
Centrosomes, the major microtubule organizing centers, facilitate mitotic spindle formation. However, recent studies have revealed that some cancer cells lack centrosomes. These findings suggest that certain types of cancer cells drive centrosome-independent mechanisms for the assembly of mitotic sp …
📰 "Cell motility, cytoskeleton, and motor proteins-21st IUPAB Congress session commentary"
https://pubmed.ncbi.nlm.nih.gov/39618794/ #CytoskeletonCell motility, cytoskeleton, and motor proteins-21st IUPAB Congress session commentary - PubMed
The cytoskeleton is the major mechanical unit of the cell and is essential for cellular processes such as motility, division, and contraction. It consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-along with passive cross-linkers and active motor protein …
📰 "Nonthermal fluctuations accelerate biomolecular motors"
https://pubmed.ncbi.nlm.nih.gov/39618792/ #KinesinNonthermal fluctuations accelerate biomolecular motors - PubMed
Intracellular transport is essential for maintaining cellular function. This process is driven by different mechanisms in prokaryotic and eukaryotic cells. In small prokaryotic cells, diffusion is the primary means of transport, while larger eukaryotic cells also rely on active transport by molecula …
📰 "Microtubule choreography: spindle self-organization during cell division"
https://pubmed.ncbi.nlm.nih.gov/39618782/ #MicrotubuleMicrotubule choreography: spindle self-organization during cell division - PubMed
During cell division, the network of microtubules undergoes massive rearrangement to self-organize into the spindle, a bipolar structure essential for accurate chromosome segregation. This structure ensures the stable transmission of the genome from the mother cell to two daughter cells, yet the pro …
