๐ฐ "KIF18A Maintains Kinetochore-Microtubule Attachments in CIN Cells by Limiting Microtubule Polymerization"
https://www.biorxiv.org/content/10.64898/2026.04.15.718686v1?rss=1 #Microtubule #Kinesin๐ฐ "KIF18A Maintains Kinetochore-Microtubule Attachments in CIN Cells by Limiting Microtubule Polymerization"
https://www.biorxiv.org/content/10.64898/2026.04.15.718686v1?rss=1 #Microtubule #Dynamics #Kinesin
Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch
Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.
Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch
Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.
๐ฐ "KIF18B Modulates SKP2 Ubiquitination to Promote Aerobic Glycolysis and Osteosarcoma Progression"
https://doi.org/doi:10.3390/ijms27073235https://pubmed.ncbi.nlm.nih.gov/41977416/ #CellDivision #Kinesin๐ฐ "KIF18B Modulates SKP2 Ubiquitination to Promote Aerobic Glycolysis and Osteosarcoma Progression"
https://doi.org/doi:10.3390/ijms27073235https://pubmed.ncbi.nlm.nih.gov/41977416/ #Kinesin๐ฐ "RETRACTION: Kinesin Family Member 2A High Expression Correlates With Advanced Tumor Stages and Worse Prognosis in Non-Small Cell Lung Cancer Patients"
https://doi.org/doi:10.1002/jcla.70236https://pubmed.ncbi.nlm.nih.gov/41972894/ #Kinesin๐ฐ "In vitro reconstitution defines the mechanistic basis of HSET motor activity regulation by IntraFlagellar Transport proteins"
https://doi.org/doi:10.1038/s42003-026-10007-3https://pubmed.ncbi.nlm.nih.gov/41963464/ #Kinesin๐ฐ "Force-Regulated Multimotor Coordination Drives Bidirectional Lipid Droplets Transport in Tunneling Nanotubes"
https://doi.org/doi:10.1021/acsnano.6c00959https://pubmed.ncbi.nlm.nih.gov/41955523/ #Kinesin๐ฐ "Force-Regulated Multimotor Coordination Drives Bidirectional Lipid Droplets Transport in Tunneling Nanotubes"
https://doi.org/doi:10.1021/acsnano.6c00959https://pubmed.ncbi.nlm.nih.gov/41955523/ #Mechanical #Kinesin #Force
Rxiv cytoskeleton
Rxiv mechanobio