LED3hub

@[email protected]
33 Followers
6 Following
384 Posts
Leiden Early Drug Discovery & Development (LED3) is a hub of scientists working on early drug discovery at the Leiden Institute of Chemistry, the Leiden Academic Centre for Drug Research, the Institute of Biology Leiden and the Leiden Institute of Advanced Computer Science.
Homepagehttps://www.universiteitleiden.nl/en/science/led3
Homepagehttps://www.universiteitleiden.nl/en/science/led3/led3-lectures
Blueskyhttps://bsky.app/profile/led3hub.bsky.social
Twitterhttps://twitter.com/LED3hub
Show threadLED3hub1h ago

Huge congratulations to Hermen Overkleeft on this very well deserved award! (5/5)

#ChemBio #Chemistry #Glycotime #Award #SpinozaPrize #LeidenUniversity #DrugDiscovery #Innovation #NWO

https://www.nwo.nl/prof-dr-hermen-overkleeft

Prof. dr. Hermen Overkleeft | NWO

Hermen Overkleeft wordt wereldwijd beschouwd als een van de grondleggers van de chemische biologie. Dit vakgebied ontwerpt moleculen om biologische processen te doorgronden. De hoogleraar bio-organische chemie aan de Universiteit Leiden ontwikkelde innovatieve methodes om menselijke eiwitten effectief en zonder nadelige gevolgen te kunnen beïnvloeden. Hiermee heeft hij niet alleen de kennis over metabole processen in het lichaam verrijkt, maar ook de ontwikkeling van nieuwe geneesmiddelen mogelijk gemaakt. Voor deze uitzonderlijke prestaties ontvangt Overkleeft de Spinozapremie.

NWO
Show threadLED3hub1h ago
His fundamental scientific work has laid the foundation for three start-up companies (AZAFAROS B.V., iProtics and AVIGI Therapeutics) that are driving these developments forward to the clinics in order to hopefully help patients in the future. (4/5)
Show threadLED3hub1h ago
In this context, his group's work is highlighted by the combination of excellent organic synthesis and chemical biology. He is maybe best known for his pioneering work on activity-based protein profiling (ABPP) approaches to study sugar-modifying enzymes in complex biological systems. (3/5)
Show threadLED3hub1h ago

Awarded by NWO, the Spinoza Award is the highest scientific award in the Netherlands.

Hermen Overkleeft is recognized for his groundbreaking contributions to developing chemical tools that allow us to better understand biological systems. (2/5)

LED3hub1h ago

Spinoza Award for Chemical Biologist Hermen Overkleeft from Leiden University!

We are extremely excited that Hermen Overkleeft from the Leiden Institute of Chemistry and our @LED3hub was awarded the highly prestigious Spinoza Award. (1/5)

https://www.universiteitleiden.nl/en/news/2026/06/spinoza-prize-for-chemical-biologist-hermen-overkleeft

Spinoza Prize for chemical biologist Hermen Overkleeft

Professor of Bio-organic Chemistry Hermen Overkleeft develops innovative methods to study disease processes. This increases our understanding of the human body and enables the development of new medicines. Overkleeft has been awarded the Spinoza Prize: the most prestigious scientific award in the Ne…

Leiden University
LED3hub4h ago
Stephan Hacker6h ago

Amazing news that Hermen Overkleeft of @LED3hub and the Leiden Institute of Chemistry of Leiden University was awarded the Spinoza Award!

The Spinoza Award is the highest scientific Award of the Netherlands.

https://www.nwo.nl/en/professor-hermen-overkleeft
#ChemBio #Chemistry #Glycotime #DrugDiscovery #Award

Professor Hermen Overkleeft | NWO

Hermen Overkleeft is known worldwide as one of the founders of chemical biology. This is the field that designs molecules to analyse biological processes. As a professor of bio-organic chemistry at the University of Leiden, Hermen Overkleeft has developed innovative methods to effectively influence human proteins without any harmful side effects. This has not only yielded valuable knowledge about metabolic processes in the human body, but has also led to the development of new drugs. Professor Overkleeft is awarded with the NWO Spinoza Prize for these remarkable achievements.

NWO
LED3hub21h ago
Stephan Hacker21h ago

Inspiring @LED3hub Lecture by Madelon Maurice. She talked about SureTACs as a modality for lysosomal degradation of membrane proteins by engaging membrane-bound E3 ligases using antibodies.

https://worldwide.espacenet.com/patent/search/family/074844924/publication/US2023142972A1?q=pn%3DUS2023142972A1

#Chemistry #ChemBio #DrugDiscovery #TPD #Degrader

LED3hub21h ago

We are very happy that Madelon Maurice from UMC Utrecht and Oncode Institute visited us today for a LED3 Lecture. She talked about "SureTACs: A novel modality for targeted degradation of cell surface proteins".

#DrugDiscovery #TPD #Degraders #ChemBio #Chemistry

LED3hubJun 18
Stephan HackerJun 18

RE: https://mstdn.science/@LED3hub/116769930240116706

Check out the program for the @LED3hub Lectures of the coming academic year. It would be great to see many of you there!

Show threadLED3hubJun 18
We want to thank the organizers of this lecture series for putting this amazing program together:
Anne Wentink
Sandra Irmisch
Nathaniel Martin
Sebastian Pomplun
Kim Bonger
Rob van Wijk
Stephan M. Hacker
(7/7)