We are looking forward to the LED3 Lecture by Jon Stokes on May 28th. He will talk about "An honest discussion about AI for antibiotic discovery "
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
We are very happy that Peng Chen from Peking University visited us today for a very well attended LED3 Lecture. He talked about "Live-cell Protein Chemistry in Health and Disease".
We are looking forward to the LED3 Lecture by Peng Chen on April 23rd. He will talk about "Live-cell Protein Chemistry in Health and Disease"
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
We are very happy that Thomas Clairfeuille from Roche visited us today for a very well attended LED3 Lecture. He talked about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".
https://www.nature.com/articles/s41586-023-06873-0
#Antibiotics #DrugDiscovery #ChemBio #Chemistry
We are looking forward to the LED3 Lecture by Thomas Clairfeuille from the Roche Innovation Center on March 26th. He will talk about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
Our theme leader, Mario van der Stelt, introduces our LED3 hub at the meeting of all of our faculty priority themes of our Science Faculty. Great discussions on the annual and communication plan as well as the outlook for the future. Many exciting things are ahead.
We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
New preprint from our LED3 hub, now on ChemRxiv!
The labs of Sebastian Pomplun, Gerard van Westen and Laura Heitman at the Leiden Academic Centre for Drug Research with first author Sean M. McKenna present COMBINAUT: an automated parallel synthesis platform enabling rapid access to a 22.9M-member synthetically accessible chemical space for fast validation of virtual screening hits.
https://chemrxiv.org/doi/full/10.26434/chemrxiv.15000200/v1
#DrugDiscovery #Automation #VirtualScreening #MedicinalChemistry #HitDiscovery
How do mycobacteria assemble their highly impermeable outer cell envelope?
In their new bioRxiv preprint, the group of Sebastian Geibel of our LED3 hub has addressed an important aspect of this question. Using cryoEM, they elucidated the structure of two long-chain acyl-CoA carboxylase (LCC) complexes that are key to mycolic acid and complex lipid biosynthesis.
Congratulations to all authors!
https://www.biorxiv.org/content/10.64898/2026.02.06.704326v2
#Chemistry #DrugDiscovery #cryoEM #structure #Mycobacteria #Tuberculosis
We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
