We have just updated our server! 😎 If you experience any issue uploading PDBs, AF or own structures, just clear the cache and you'll good to go!
Very cool updates are about to come, so follow us here or on our shiny new bsky account 
| #glycotime |
GlycoShape
- 22 Followers
- 18 Following
- 43 Posts
GlycoShape is an OA database of glycans 3D structural data and information that can be downloaded and/or used with Re-Glyco to rebuild glycoproteins from the RCSB PDB or EMBL-EBI AlphaFold repositories or own. GlycoShape can also predict N-glycosylation occupancy with GlcNAc Scanning. Developed and curated by Elisa Fadda research group @Elisa
You may wonder, why are sugars important in biology, biotechnology and medicine?
Check this out ⬇️ this phenomenal achievement from the work of Prof Stephen Withers and Prof Jayachandran Kizhakkedathu and team (over MANY years)!
NCFG🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in everything from gene expression to cell survival. Learn about O-GlcNAc & more!
👉 https://research.bidmc.org/ncfg/blog/21-facts-about-intracellular-protein-glycosylation
#glycans #proteinmodification #glycosylation #posttranslationalmodification #cellbiology #science #glycotime
Our latest blog on interesting facts about glycans we dig deeper into the UDP-glucuronic acid and glucuronyltransferases in the endoplasmic reticulum - which can be critical in drug metabolism.
Read at: https://research.bidmc.org/ncfg/blog/facts-about-udp-glucuronic-acid-and-glucuronosyltransferases-er
*Note: pun intended 😜
A spoonful of sugar #18 🍬
Plant receptor kinases translate and pass on chemical messages as part of many key biological processes. A new fabulous cryo-EM structure of the active complex between the kinase MIK2, the immunomodulatory peptide SCOOP and the co-receptor BAK1 shows how its binding hinges on N-glycosylation (https://doi.org/10.1038/s41477-024-01841-6)
You can rebuilt the fully glycosylated structure of the complex with https://glycoshape.org with some fancy-plant N-glycans
@MissGayle We are based in the UK, luckily! But we are always making plans :P
On this page we are focusing on #science, yet we are not immune to the political and social environment around all of us
We are a small research group interested in all about sugar biology 🍬 structural biology 🌱 (see above) and computational biophysics 💻
We operate *exclusively* here on #mastodon #fediverse, where the scientific discourse needs to be better supported
We think we are doing our bit, please support (👍+ReTooT) #science posts to amplify scientific content on free servers!
A spoonful of sugar #17 🍬
Everyone needs a bit of sugar today, here is a treat
The oligosaccharyltransferase, or OST (EC 2.4.1.119), is a key enzyme that functionalizes nascent proteins with sugars called N-glycans
The 3D structure of this magnificent molecular machine has been solved by cryo-EM by Ana Ramirez et al. (PDB 8AGC) https://doi.org/10.1038/s41467-022-35067-x
Be like OST and plant one of the 195 N-glycans 🌱 online on your protein 3D structure with https://glycoshape.org
A spoonful of sugar #16 🍬
How does glycosylation affect not only structure and function of proteins, but also binding specificity?
In a new paper fresh off the #bioRxiv press https://doi.org/10.1101/2024.10.24.620132 in collaboration with Nicki Packer, Len Harrison and Ethan Goddard-Borger, we explain how glycosylation of CD52 (reconstructed with https://glycoshape.org) determines:
1) the peptide's conformation,
2) binding to the HMGB1 Box B and only then
3) to SIGLEC-10
