π€― Did you know proteins inside cells can be glycosylated?! π¬ Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in everything from gene expression to cell survival. Learn about O-GlcNAc & more!
π https://research.bidmc.org/ncfg/blog/21-facts-about-intracellular-protein-glycosylation
#glycans #proteinmodification #glycosylation #posttranslationalmodification #cellbiology #science #glycotime
https://www.nature.com/articles/s41467-023-37287-1
"Daptides uniquely harbor two positively charged termini, and thus we suspect this modification could aid in membrane targeting, as corroborated by hemolysis assays. Our studies further show that the oxidative decarboxylation step requires a functionally unannotated accessory protein."
#molecules #biochemistry #peptides #postTranslationalModification
RiPP discovery has expanded the scope of post-translational modification chemistry, but genome mining of RiPP classes remains an unsolved challenge. Here, the authors employed bioinformatics and synthetic biology approaches to discover and characterize an unknown class of RiPPs, defined by an unusual amino-modified C-terminus.
NCFG
katch wreck
Karla Feijs