Extremely happy to share our last paper in @[email protected] with the community! Big team effort, congrats and a huge thank you to all authors, it was a pleasure to work with all of you on this! 🥳🥳🥳 #immunogenomics #TME #brain_metastasis https://twitter.com/johanna_a_joyce/status/1615376628317650949
🐦🔗: https://twitter.com/aalvarezprado/status/1615383584436633603
“How do cancer cells sculpt their tumor microenvironment??🤔 We analyzed brain metastases, from lung or breast primary cancers - and associated w/ different genetic alterations, to reveal distinct immune cell landscapes and phenotypes ⏬ https://t.co/b4j2P5phI9 #openaccess #TME”
I am looking for a T cell immunologist who loves flow cytometry! Come and do a postdoc in my friendly, collaborative lab. Job listing here!
https://www.immunology.org/careers/bsi-jobs-board
🐦🔗: https://twitter.com/GwyerFindlay/status/1612827782358212608
Very excited to share a new paper from my lab: using a set chromosome-engineering tools, we show that cancers are “addicted” to aneuploidy. If you genetically eliminate single aneuploid chromosomes, cancer cells totally lose their malignant potential!
https://www.biorxiv.org/content/10.1101/2023.01.09.523344v1
🐦🔗: https://twitter.com/JSheltzer/status/1612856285850128390
A great read to close out the year: radially expanding populations decrease competition as they grow (because of expanding available area or volume), which facilitates the survival of unfit mutants and downstream acquisition of compensatory mutations. This can underlie the evolution of resistance to treatment in bacterial biofilms and solid tumors.
Antibiotic and anti-cancer therapy are challenged by mutation-mediated treatment resistance despite many mutations being maladaptive. Here, the authors introduce a system that shows how the probability of the long-term persistence of drug-resistant mutant lineages can be increased in dense microbial populations by acquiring multiple mutations.