| Lab | https://agora-cancer.ch/laboratory/carmona-lab/ |
| GitHub | https://github.com/carmonalab |
| https://twitter.com/carmonation |
We believe in you. Best of luck, @[email protected]
From today, our new publishing model comes into full effect.
Your research can now be published as a Reviewed Preprint, with nuanced, high-quality public peer reviews and new eLife assessments.
Learn more: https://elifesciences.org/inside-elife/741dbe4d?utm_source=twitter&utm_medium=social&utm_campaign=organic
🚨Hiring alert for a new #ELISIR scholar 🚨
From outstanding #PhD straight to independent #GroupLeader in Lausanne, Switzerland! Conduct research in #LifeSciences - 2023 call prioritizes theoretical and computational biology
Nominations + applications 👉https://go.epfl.ch/ELISIR
Looking for a PI position? Come join us in Munich! Institute of AI for Health is hiring! https://twitter.com/FeestChristoph/status/1616054649697759232
🐦🔗: https://twitter.com/MDLuecken/status/1616076020301398019
Thrilled to kick off the holiday season with a new paper from the lab! Out in @[email protected] today, we explore an unexpected function of terminally exhausted T cells and their contribution to the immunosuppressive tumor microenvironment. 🧵 1/ https://www.nature.com/articles/s41590-022-01379-9
🐦🔗: https://twitter.com/DelgoffeLab/status/1605606197960351745
Exhausted CD8+ T cells with diminished effector functions accumulate in tumors. Here, the authors show that hypoxia induces a suppressive phenotype in exhausted T cells and that interfering with hypoxia-mediated CD39 expression limits immunosuppression in the tumor and augments immunotherapy, resulting in arrest of tumor growth.
This 2021 @[email protected] paper is one of the best #DataScience #Bioinformatics resources out there for understanding the genetic determinants of response to immune checkpoint inhibitors (ICIs).
🐦🔗: https://twitter.com/simocristea/status/1615402486764040194
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @[email protected] https://www.nature.com/articles/s41586-022-05626-9
🐦🔗: https://twitter.com/Masopust_Vezys/status/1615785991154843670
Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.
Extremely happy to share our last paper in @[email protected] with the community! Big team effort, congrats and a huge thank you to all authors, it was a pleasure to work with all of you on this! 🥳🥳🥳 #immunogenomics #TME #brain_metastasis https://twitter.com/johanna_a_joyce/status/1615376628317650949
🐦🔗: https://twitter.com/aalvarezprado/status/1615383584436633603
“How do cancer cells sculpt their tumor microenvironment??🤔 We analyzed brain metastases, from lung or breast primary cancers - and associated w/ different genetic alterations, to reveal distinct immune cell landscapes and phenotypes ⏬ https://t.co/b4j2P5phI9 #openaccess #TME”
Excited to share our 🆕 comprehensive review on T follicular helper cells in cancer in @[email protected]! https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00270-9#.Y8XYYcplpxY.twitter This work was spearheaded by talented @[email protected], with a focus on the role of Tfh cells in solid tumors & irAEs. @[email protected] @[email protected] @[email protected]
🐦🔗: https://twitter.com/BaumjohannLab/status/1615248026456530944
Are you interested in the intersection of chemogenomics, machine learning and drug discovery? Our new review, "Targeting Trypanosomes: How Chemogenomics and Artificial Intelligence Can Guide Drug Discovery," is sure to get your attention!
🐦🔗: https://twitter.com/leitouran/status/1612586065763745792
Trypanosomatids are protozoan parasites that cause human and animal neglected diseases. Despite global efforts, effective treatments are still much needed. Phenotypic screens have provided several chemical leads for drug discovery, but the mechanism of action for many of these chemicals is currently unknown. Recently, chemogenomic screens assessing the susceptibility or resistance of parasites carrying genome-wide modifications started to define the mechanism of action of drugs at large scale. In this review, we discuss how genomics is being used for drug discovery in trypanosomatids, how integration of chemical and genomics data from these and other organisms has guided prioritisations of candidate therapeutic targets and additional chemical starting points, and how these data can fuel the expansion of drug discovery pipelines into the era of artificial intelligence.
After more than 2 years of work, I am happy to share our latest preprint on CellCharter, a computational framework to identify and study cellular niches in large-scale spatial transcriptomics and proteomics data 🧵 1/12
https://www.biorxiv.org/content/10.1101/2023.01.10.523386v1
🐦🔗: https://twitter.com/MarcoVarrone/status/1613463315547672581
