Pablo Cárdenas R.

@[email protected]
277 Followers
240 Following
244 Posts

PhD candidate @MIT Dept. of Biological Engineering • 🦟 🦠 🧬 🇨🇴 •
#Pathogens, computational + synthetic #biology (#synbio), #epidemiology, #evolution

Yes my initials are PCR but that hasn't made me better at it

coming from twitter @pcr_guy, trying threads @pcr.guy

Websitehttps://pablo-cardenas.com
Blueskyhttps://bsky.app/profile/pcr-guy.bsky.social
Twitterhttps://twitter.com/pcr_guy
Pablo Cárdenas R.Sep 29, 2023
Aaand that’s a wrap, see you next week! Stay adaptive folks
https://evoluncheons.blogspot.com/2023/09/28-sep-2023.html
28 Sep 2023

Hello interwebz!   Back for #Evoluncheons after a week of travel and drowning in a sea of papers. This took all day again -_-    Actually or...

Show threadPablo Cárdenas R.Sep 29, 2023

Zoonoses:

9. Host traits shape virome composition and virus transmission in wild small mammals. 534 new viruses found in bats, shrews, and rodents; inter-species transmission events identified. https://doi.org/10.1016/j.cell.2023.08.029

Show threadPablo Cárdenas R.Sep 29, 2023
Exhaustive author’s thread: https://twitter.com/iamsamayp/status/1706100974816006606
Samay Pande on X

1/n Preprint alert📢: Happy to present insanely cool work led by super talented PhD student @JyoKalathera , and superbly supported by Vishwa who was a research fellow in the lab. Here is the thread to tell you a bit about this manuscript. https://t.co/Dvbk13hvHA

X (formerly Twitter)
Show threadPablo Cárdenas R.Sep 29, 2023
8. Bottlenecks affect different cooperative traits in different ways in the social bacterium Myxococcus xanthus, selecting for some and against others. https://doi.org/10.1101/2023.09.20.558552
Show threadPablo Cárdenas R.Sep 29, 2023
…feels great to add old colleagues and professors to this newsletter. Author post (and link to great spanish-language breakdown on igram): https://twitter.com/cdanielcadena/status/1705213834653249547
daniel cadena on X

our latest, led by @AtiQuinones - theory and models inspired by one of the systems we study in nature leads to insights that make us think about our empirical work in novel ways. #cienciacriolla

X (formerly Twitter)
Show threadPablo Cárdenas R.Sep 29, 2023

Behavior:

7. Simulations of agents engaging in pairwise fights and status signaling show that honest and dishonest-signaling individuals can coexist if costs of signaling are not proportional to quality and individuals can learn from experience. https://doi.org/10.1101/2023.09.19.558427

Show threadPablo Cárdenas R.Sep 29, 2023
Cancer:
6. Single-cell phylogenies reveal changes in the evolutionary rate within cancer and healthy tissues. A new statistical test detects changes in mutation rate across a variety of cancer and healthy somatic tissues using scDNA-seq data.
https://doi.org/10.1016/j.xgen.2023.100380
Show threadPablo Cárdenas R.Sep 29, 2023
Author's tweetorial: https://twitter.com/dposada_/status/1701977917599703117
David Posada on X

Check our new paper on changes in the evolutionary rate among somatic lineages! https://t.co/fxuyZtLBNl A nice collaboration with Nico Borgsmüller, @linkmonica, Jack Kuipers, and Niko Beerenwinkle

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Show threadPablo Cárdenas R.Sep 29, 2023

Engineering:

5. Genetic variation derived from adaptive laboratory evolution of E. coli to specific conditions and standing variation in wild strains are largely non-overlapping evolutionary spaces that be combined in directed evolution and strain design.
https://doi.org/10.1101/2023.09.17.558058

Show threadPablo Cárdenas R.Sep 29, 2023
High host growth favors selection of resistant mutants, high pathogen transmission favors acquired CRISPR immunity.