How can we develop new antibiotics against the most devastating infections with antibiotic-resistant Gram-negative bacteria?
Thomas Clairfeuille gave an inspiring lecture on this topic in his
@[email protected] Lecture. (1/8)
www.nature.com/articles/s41...He described the discovery and development of the antibiotic zosurabalpin against carbapenem-resistant Acinetobacter baumannii (CRAB). (2/8)
He started with the interesting insight, that synthetic compounds can have a big advantage over natural compounds for the development of antibiotics as they have not already undergone a long history of evolutionary selection that can lead to resistance development in nature. (3/8)
He then talked about the discovery of zosurabalpin based on the screen of a library of cyclic tripeptides and gave important insights into all the challenges that they faced and resolved during the development of this compound. (4/8)
Stephan Hacker