Mastodawn

He also hinted at a new class of synthetic antibiotics that is in current development at Roche. Hopefully there are many more new antibiotics in the future. (7/7)

#Antibiotics #DrugDiscovery #DrugDevelopment #ChemBio #Chemistry #cryoEM #AMR #Resistance #Bacteria #SAR #Synthesis #Zosurabalpin

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Stephan Hacker 4d ago

He also hinted at a new class of synthetic antibiotics that is in current development at Roche. Hopefully there are many more new antibiotics in the future. (8/8) #Antibiotics #DrugDiscovery #DrugDevelopment #ChemBio #Chemistry #cryoEM #AMR #Resistance #Bacteria #SAR #Synthesis #Zosurabalpin

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Stephan Hacker Mar 9

If you are interested, make sure to come by! More information can be found here: www.universiteitleiden.nl/en/science/l... #Antibiotics #DrugDiscovery #LPS #Bacteria #Zosurabalpin #Chemistry #ChemBio

LED3 Lectures

LED3 Lectures

The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institute of Advanced Computer Science (LIACS), is very excited to organize the “LED3 Lectures”. This lecture…

Leiden University

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Stephan Hacker Mar 9

If you are interested, make sure to come by! More information can be found here: https://www.universiteitleiden.nl/en/science/led3/led3-lectures
(2/2)

#Antibiotics #DrugDiscovery #LPS #Bacteria #Zosurabalpin #Chemistry #ChemBio

LED3 Lectures

Leiden University

Benjamin Carr, Ph.D. 👨🏻‍💻🧬Jan 22, 2024

Experimental #antibiotic kills deadly #superbug, opens whole new class of #drugs
Relatively large molecule clogs a transport system, leading to lethal toxicity. In this case, the new #drug—dubbed #zosurabalpin—fights off the #GramNegative #bacterium carbapenem-resistant Acinetobacter baumannii, aka CRAB. Though it may sound obscure, it's an opportunistic, invasive #bacteria that often strikes hospitalized and critically ill patients, causing deadly #infections worldwide. https://arstechnica.com/science/2024/01/experimental-antibiotic-reveals-entirely-new-way-to-kill-drug-resistant-bacteria/

Experimental antibiotic kills deadly superbug, opens whole new class of drugs

The relatively large molecule clogs a transport system, leading to lethal toxicity.

Ars Technica

Boris Tefsen Jan 13, 2024

The new #antibiotic #Zosurabalpin traps a substrate-bound conformation of the #lipopolysaccharide (LPS) transporter #Lpt by recognizing a composite binding site made up of both Lpt and its substrate. #LPS

https://www.nature.com/articles/s41586-023-06799-7

A new antibiotic traps lipopolysaccharide in its intermembrane transporter - Nature

A mechanism of lipid transport inhibition has been identified for a class of peptide antibiotics effective against resistant Acinetobacter strains, which may have applications in the inhibition of other Gram-negative pathogens.

Nature

Matt Willemsen Jan 8, 2024

Experimental antibiotic kills deadly superbug, opens whole new class of drugs
https://arstechnica.com/science/2024/01/experimental-antibiotic-reveals-entirely-new-way-to-kill-drug-resistant-bacteria/ #experimental #antibiotic #superbug #drugs #GramNegative #bacteria #zosurabalpin #CRAB

Experimental antibiotic kills deadly superbug, opens whole new class of drugs

The relatively large molecule clogs a transport system, leading to lethal toxicity.

Ars Technica

Chuck Darwin Jan 6, 2024

A new experimental antibiotic can handily knock off one of the world's most notoriously drug-resistant and deadly bacteria —in lab dishes and mice, at least.

It does so with a never-before-seen method, cracking open an entirely new class of drugs that could yield more desperately needed new therapies for fighting drug-resistant infections.

The new drug—dubbed #zosurabalpin—fights off the Gram-negative bacterium carbapenem-resistant Acinetobacter baumannii, aka #CRAB.

Though it may sound obscure, it's an opportunistic, invasive bacteria that often strikes hospitalized and critically ill patients, causing deadly infections worldwide.

It is extensively drug-resistant, with ongoing emergence of pan-resistant strains around the world—in other words, strains that are resistant to every current antibiotic available.

Mortality rates of invasive CRAB infections range from 40 to 60 percent.

In 2017, the World Health Organization listed it as a priority 1: critical pathogen, for which new antibiotics are needed most urgently.

https://arstechnica.com/science/2024/01/experimental-antibiotic-reveals-entirely-new-way-to-kill-drug-resistant-bacteria/