mymedschoolNov 8

Understand catalase-positive organisms and their role in infections, especially in chronic granulomatous disease. #CatalasePositive #Microbiology #CGD #Immunology #Staphylococcus #Pseudomonas #Serratia #Nocardia #Aspergillus #USMLE #MedicalEducation #Pathogenesis #OxidativeBurst

https://mymedschool.org/portfolio/u01-03-008-catalase-positive-organisms/?utm_source=mastodon&utm_medium=jetpack_social

Chronic Granulomatous Disease (CGD) Pathophysiology: Catalase-Positive Infections Explained

Master the key features of chronic granulomatous disease (CGD) with this interactive drag-and-drop exercise. Learn why NADPH oxidase defects increase susceptibility to catalase-positive bacteria like Staphylococcus aureus and not Streptococcus. Ideal for USMLE Step 1 prep and clinical understanding.

mymedschool.org
Giuseppe MichieliAug 14, 2025

#Italy, #Serratia #bacteria is likely behind the death of two preterm babies in #Bozen https://www.ilfattoquotidiano.it/2025/08/14/serratia-marcescens-batterio-neonati-bolzano-notizie/8095181/

#PICU #infections #pediatrics

Serratia marcescens, cos’è il batterio che ha ucciso due neonati prematuri a Bolzano

Il batterio che ha ucciso due neonati a Bolzano può essere letale per i pazienti con compromissione immunitaria

Il Fatto Quotidiano
tangyFeb 7, 2025

It's finally published! A possible hospital-associated national outbreak where investigation ultimately did not lead to identification of the source.

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.5.2400291

#Norway #Serratia #Outbreak

Eurosurveillance | A national outbreak of Serratia marcescens complex: investigation reveals genomic population structure but no source, Norway, June 2021 to February 2023

We report a national outbreak of Serratia marcescens complex type 755 (ct755) in Norway, with 74 cases identified between June 2021 and February 2023. Careful reviews of patient journals and interviews were performed, involving 33 hospitals throughout Norway. All available clinical isolates of S. marcescens collected between January 2021 and February 2023 (n = 455, including cases) from all involved hospitals were whole genome sequenced. Cases displayed a pattern of opportunistic infections, as usually observed with S. marcescens. No epidemiological links, common exposures or common risk factors were identified. The investigation pointed to an outbreak source present in the community. We suspect a nationally distributed product, possibly a food product, as the source. Phylogenetic analysis revealed a highly diverse bacterial population containing multiple distinct clusters. The outbreak cluster ct755 stands out as the largest and least diverse clone of a continuum, however a second cluster (ct281) also triggered a separate outbreak investigation. This report highlights challenges in the investigation of outbreaks caused by opportunistic pathogens and suggests that the presence of identical strains of S. marcescens in clinical samples is more common than previously recognised.

Sigrid NeuhauserApr 25, 2024

Guten Morgen! Was war gestern schön was hat euch gefreut? Es sind die kleinen Dinge die zählen.

Heute ausnahmsweise Bakterien: die roten Kolonien sind vermutlich Serratia marcescens. Dieses Bakterium ist für viele mittelalterliche Blutwunder verantwortlich. Die Rote Färbung und dass Kolonien schleimige Filme auf feuchten Oberflächen bilden erklärt wie z.B. Hostien über Nacht mit "Blut" durchtränkt waren oder blutige Tränen an Statuen.
#diekleinendinge #microbiology #serratia #biodiversity

CellBioNewsApr 20, 2023

New #cell-killing #toxin discovered in an environmental #pathogen.

#Ssp #Serratia #bacteria

https://phys.org/news/2023-04-cell-killing-toxin-environmental-pathogen.html

New cell-killing toxin discovered in an environmental pathogen

Using the Australian Synchrotron researchers at the La Trobe Institute for Molecular Science (LIMS) and the French National Research Institute for Agriculture, Food and Environment were able to see the molecular structure of the Ssp toxin from the bacterial pathogen Serratia marcescens. Researchers estimate that the structure of a new toxin class has not been determined in almost a decade.

Phys.org