PLOS BiologySep 15, 2025
What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @PLOSBiology https://plos.io/46cBaE4
Amelia Cervera 🧬Feb 7, 2025
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci.
#GeneEditing #Transposons #R2 #Retroelements
https://www.nature.com/articles/s41587-024-02137-y
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci - Nature Biotechnology

Transgenes are inserted into human cells by 2-RNA delivery of a retroelement protein and template.

Nature
katch wreckJul 13, 2023

`Together, our study reveals that alt-EJ is essential in driving the propagation of #parasitic #genomic #retroelements. Our study uncovers a conserved function of this understudied #DNA #repair process, and provides a new perspective to understand—and potentially control—the #retrotransposon life cycle`

https://www.nature.com/articles/s41586-023-06327-7

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis - Nature

Retrotransposons hijack the alternative end-joining DNA repair process of the host for a circularization step to synthesize their second-strand DNA.

Nature