Día mundial de la Osteogénesis Imperfecta 2025 - Somosdisc@
Cada 6 de mayo se celebra el día mundial de la Osteogénesis Imperfecta, más conocida como la enfermedad de los huesos de cristal.
Día mundial de la Osteogénesis Imperfecta 2024 - Somosdisc@
Cada 6 de mayo se celebra el día mundial de la Osteogénesis Imperfecta, más conocida como la enfermedad de los huesos de cristal.
Researchers identify molecular basis for morphological diversity of amniote skull
A research group led by Associate Professor Masayoshi Tokita explored the molecular basis generating the diversity of amniote skull morphology, using embryos of several amniote species as materials.
Día mundial de la Osteogénesis Imperfecta 2023 - Somosdisc@
Cada 6 de mayo se celebra el día mundial de la Osteogénesis Imperfecta, más conocida como la enfermedad de los huesos de cristal
Local implant of #BMP2-loaded GelMA hydrogel improves #Osteogenesis+#Angigoenesis in rat critical-size Mandibular defect
⏫type H CD31+Emcn+ vessel
⏫Perivascular Osx+ osteoprogenitor
⏫CD51+ #SkeletalStemCell
Dr. L. Qin & J. Xu labs Pharmaceutics 2022
https://www.mdpi.com/1999-4923/14/11/2397
Controlled Release of Bone Morphogenetic Protein-2 Augments the Coupling of Angiogenesis and Osteogenesis for Accelerating Mandibular Defect Repair
Reconstruction of a mandibular defect is challenging, with high expectations for both functional and esthetic results. Bone morphogenetic protein-2 (BMP-2) is an essential growth factor in osteogenesis, but the efficacy of the BMP-2-based strategy on the bone regeneration of mandibular defects has not been well-investigated. In addition, the underlying mechanisms of BMP-2 that drives the bone formation in mandibular defects remain to be clarified. Here, we utilized BMP-2-loaded hydrogel to augment bone formation in a critical-size mandibular defect model in rats. We found that implantation of BMP-2-loaded hydrogel significantly promoted intramembranous ossification within the defect. The region with new bone triggered by BMP-2 harbored abundant CD31+ endomucin+ type H vessels and associated osterix (Osx)+ osteoprogenitor cells. Intriguingly, the new bone comprised large numbers of skeletal stem cells (SSCs) (CD51+ CD200+) and their multi-potent descendants (CD51+ CD105+), which were mainly distributed adjacent to the invaded blood vessels, after implantation of the BMP-2-loaded hydrogel. Meanwhile, BMP-2 further elevated the fraction of CD51+ CD105+ SSC descendants. Overall, the evidence indicates that BMP-2 may recapitulate a close interaction between functional vessels and SSCs. We conclude that BMP-2 augmented coupling of angiogenesis and osteogenesis in a novel and indispensable way to improve bone regeneration in mandibular defects, and warrants clinical investigation and application.
Featured in issue 23 of our anniversary year:
How delayed folding aids #protein secretion
Plant and mammalian #ubiquitin E3 #ligases against #bacterial #infection
#CryoEM glimpses at membrane pore formation and #ion transporters
#Autophagosomes in need of balanced #phospholipid composition
#Hypoxia promotes #osteogenesis by facilitating #mitochondria to
#nucleus communication
Cover by by Subhash Mehto, Kautilya Kumar Jena, Santosh Chauhan et al
https://www.embopress.org/toc/14602075/2022/41/23
Somosdisca 
CellBioNews
Hao Yin
The EMBO Journal