Mastodawn

⚡By engineering lubricated interfaces inside #nanopores, researchers in the @EPFL Laboratory for Nanoscale Biology have enabled #ions to flow through a #nanofluidic membrane with unprecedented speed and control. In addition to enhancing nanofluidic technologies, the innovation could help accelerate the development of next-generation osmotic #energy harvesting. 📖 Read our news about this study, now published in Nature Energy 🔗 https://actu.epfl.ch/news/slippery-ions-create-a-smoother-path-to-blue-energ/

Science Newsroom - FSE - UG Jan 16

🐎 'Proteins are the workhorses of our cells.'

🔎 Using nanopore technology, Prof.
Giovanni Maglia developed a method to identify exactly which proteins are important to our health.

🏆 For his research, he won the FSE Impact award.

🧪 #SciComm #ScienceNewsroom #proteins #nanopores #technology #biophysics #chemistry #molecular #biology #research #Impact #science #scientistsOnMastodon @universityofgroningen

Natural Gas Industry B updates Jan 12

Multifractal analysis reveals how nanopore complexity controls gas occurrence in Zhaotong area. Mesopores and lithofacies type dominate reservoir quality in tectonically complex areas. #Openaccess at https://h7.cl/1hI8Y
#naturalgas #ShaleGas #Nanopores #EnergyGeology

EPFL Nov 13

A team of researchers has discovered how the electrical charge and internal structure of biological nanopores govern ion flow.

Their study not only provides a better understanding of two phenomena that are still poorly understood - rectification and gating - but also paves the way for applications in biosensors and ionic computing.

More info: https://actu.epfl.ch/news/nanopores-act-like-electrical-gates/

#EPFL #nanopores #science

Nanopores act like electrical gates

EPFL researchers uncover how charge and structure control ion flow in biological nanopores, paving the way for new biosensors and ion-based computing.

EPFL Nov 13

Une équipe de chercheuses et chercheurs a découvert comment la charge électrique et la structure interne des nanopores biologiques gouvernent le flux ionique.

Cette avancée permet non seulement de mieux comprendre deux phénomènes encore peu expliqués — la "rectification" et le "gating" — mais ouvre aussi la voie à des applications en biocapteurs et en informatique ionique.

Plus d'informations: https://actu.epfl.ch/news/les-nanopores-agissent-comme-des-portes-electrique/

#EPFL #nanopores

Les nanopores agissent comme des portes électriques

Une équipe de l’EPFL a découvert comment la charge et la structure contrôlent le flux ionique dans les nanopores biologiques. Cette avancée ouvre la voie à de nouveaux biocapteurs et à l’informatique basée sur les ions.

katch wreck Jul 19, 2024

new citation:

`...we highlight the engineering approaches for β-barrel-containing #nanopores used in single-molecule sensing for applications in early diagnosis & prognosis... β-barrel nanopores can be modified by genetic mutation to change the structure; alter charge distributions; or add enzymes, aptamers, and protein probes to enhance sensitivity and accuracy... this review discusses challenges & future perspectives for advancing nanopore-based diagnostic #sensors`

https://www.mdpi.com/2079-6374/14/7/345

Beta-Barrel Nanopores as Diagnostic Sensors: An Engineering Perspective

Biological nanopores are ultrasensitive and highly attractive platforms for disease diagnostics, including the sequencing of viral and microbial genes and the detection of biomarkers and pathogens. To utilize biological nanopores as diagnostic sensors, they have been engineered through various methods resulting in the accurate and highly sensitive detection of biomarkers and disease-related biomolecules. Among diverse biological nanopores, the β-barrel-containing nanopores have advantages in nanopore engineering because of their robust structure, making them well-suited for modifications. In this review, we highlight the engineering approaches for β-barrel-containing nanopores used in single-molecule sensing for applications in early diagnosis and prognosis. In the highlighted studies, β-barrel nanopores can be modified by genetic mutation to change the structure; alter charge distributions; or add enzymes, aptamers, and protein probes to enhance sensitivity and accuracy. Furthermore, this review discusses challenges and future perspectives for advancing nanopore-based diagnostic sensors.

MDPI

CellBioNews Sep 19, 2023

Have researchers found the missing link to make easy #protein #sequencing possible?.

#nanopores

https://phys.org/news/2023-09-link-easy-protein-sequencing.html

Have researchers found the missing link to make easy protein sequencing possible?

There has been a real race among scientists to create a technology that enables easy protein sequencing. Professor of Chemical Biology Giovanni Maglia of the University of Groningen has now found the missing piece in the puzzle: a way to transport a protein through a nanopore, which allows sequencing of proteins in a simple, handheld device.

Phys.org

michael May 11, 2023

8-May-2023
Using nanopore single-molecule sensing to identify #glycans
https://www.eurekalert.org/news-releases/988624 #science #nanoworld #nanopores

Using nanopore single-molecule sensing to identify glycans

Researchers have developed a glycan identification method based on nanopore single-molecule sensing through a glycan derivatization strategy.

EurekAlert!

Computomics Apr 19, 2023

Honored to be part of nanodiagbw, the #BMBF-funded Future Cluster for research on #nanopores for personalized medicine - to better understand epigenetic factors influencing widespread diseases and to be able to treat them better. 👉https://bit.ly/3MVXjPk