APLMar 10, 2025

Women with endometriosis or adenomyosis are at higher risk of long-COVID symptoms than unaffected women, likely due to immune dysregulation and chronic inflammation. Recognizing this vulnerability underscores the need for tailored therapies or preventive measures to mitigate lasting effects.

https://www.mdpi.com/3216544

#endometriosis; #adenomyosis; #long-COVID; #Immunedysregulation; #chronicinflammation.

Evaluation of Long-COVID Syndrome in a Cohort of Patients with Endometriosis or Adenomyosis

Background: Long-COVID is characterized by the persistency of COVID-19 symptoms beyond 12 weeks, and it is probably consequent to immune dysregulation induced by SARS-CoV-2 infection. Immune dysregulation is associated with and probably involved in the pathogenesis of chronic gynecological conditions like endometriosis and adenomyosis. This study evaluated whether the presence of endometriosis or adenomyosis increases the risk of long-COVID, i.e., the persistence of COVID-19 symptoms beyond 12 weeks since infection. Methods: This retrospective observational study was performed at the outpatient service for endometriosis and chronic pelvic pain, at a university hospital. The diagnosis of endometriosis/adenomyosis was primarily based on clinical symptoms and ultrasonography assessment. Data regarding infection, vaccination, symptoms associated with SARS-CoV-2 infection, and their persistence for a minimum of 12 weeks were collected. Results: This study included 247 women, 149 controls without and 98 cases with endometriosis/adenomyosis. Among these, 194 (116 controls and 78 cases) had suffered from SARS-CoV-2 infection. Rates of infection and vaccination were similar in the two groups. The distribution of the SARS-CoV-2 vaccine was uniform across the two cohorts. COVID-19 patients with endometriosis or adenomyosis exhibited a higher prevalence (p < 0.001) of dyspnea and chest pain. The prevalence of long-COVID beyond 12 weeks was higher in cases than controls (42% vs. 12%; p < 0.001) with chest pain (p < 0.001) and ageusia (p < 0.05), forming the most representative symptoms. Conclusions: Symptoms of long-COVID are more frequent in women with than without endometriosis/adenomyosis.

MDPI
Show threadLorraineJun 8, 2024

https://abcnews.go.com/GMA/GMA3/video/unusual-cancers-emerged-after-pandemic-covid-blame-110932851
SO CLOSE!!!
They’re so close to getting it😩
It’s inflammation🙄
It’s only the vulnerable🙄

There’s no excuse for this level of stupidity. NONE.

Saw a Tern post about 🚘accidents, & having been in one pretty crazy Vin Diesel one myself tipped off by a fender bender I didn’t fix months earlier… that metaphor analogy is something people will have to learn the hard way apparently

You can’t un-ring bells
#turbocancer #tcells #ImmuneDysregulation
#CovidIsNotOver #wearARespirator

Video 'Unusual' cancers emerged after the pandemic. Is COVID to blame?

A new article found that aggressive, late-stage cancers have seen an uptick following the pandemic. Is COVID to blame? Dr. Darien Sutton explains.

ABC News
JonathanJun 8, 2024

"Some emerging and re-emerging viruses of high consequence for public health such as SARS-CoV-2, Nipah virus (NiV) and Ebola virus (EBOV) are especially challenging with regards to the identification of CoP since these pathogens have been shown to dysregulate the immune response during infection.” (Escudero-Pérez et al., 2023, p. 1)

#ImmuneDysregulation

LorraineMay 22, 2024

https://archive.is/tdUM5

https://archive.is/pTvZG

the first link has some very detailed disturbing images just fyi if you’re sensitive to gruesome pics like I am… but not looking can be done😉

What’s absolutely moronic is there is ZERO mention of #sarscov2 🙄🙄🙄🙄ANYWHERE

The deliberate cloaking of harms of a highly contagious airborne virus is what infuriates me.. because if people actually knew, I can guarantee a large percentage would be behaving very differently
#sepsis #ImmuneDysregulation #foreverCovid

Show threadLorraineMay 20, 2024

https://www.cidrap.umn.edu/antimicrobial-stewardship/drug-resistant-trichophyton-fungus-represents-emerging-threat-us
#Trichophytonindotinea #Tindotineae #drugResistant #fungus #fomites #mold #ImmuneDysregulation #everythingIsFine
Every time they say rare these days….🤨🚨🚨🚨
Maybe it’s just a me thing, BUT RAMPANT FUNGUS FREAKS ME OUT🤦🏻‍♀️

If you stop the primary problem… usually it alleviates secondary issues🙄

Drug-resistant Trichophyton fungus represents emerging threat in US

CIDRAP
CurrentBiasMay 17, 2024

The evidence that covid can dysregulate the immune system is extensive, though not well-publicized. A close eye on reddit will reveal — with surprising frequency — posts asking about, or describing, anecdotal experiences with this. Here are over a dozen:

https://blog.open-source-eschaton.net/immune-dysregulation-reddit-edition

#SARSCoV2 #covid #covid19 #pandemic #PublicHealth #CovidIsNotOver #immunology #ImmuneDysregulation

[Immune Dysregulation Anecdotes: Reddit Edition]

The evidence that covid can dysregulate the immune system is extensive, though not well-publicized.

[Open-Source Eschaton]
Maxi 12x 💉Apr 8, 2024

Dieser Tagesschau-Text über #LongCovid stellt es so dar, als würde niemand Neues mehr LC bekommen, sondern es sei nur noch die Spätfolge der 'beendeten' Pandemie. Realität: Mit jeder neuen #Covid-Infektion steigt das LC-Risiko, denn Corona schädigt alle Gefäße, führt auch asymptomatisch zu Hirnschäden und die #ImmuneDysregulation durch Corona unterdrückt das Immunsystem bis auf ein Jahr.

https://www.tagesschau.de/wissen/gesundheit/long-covid-130.html?at_medium=mastodon&at_campaign=tagesschau.de

Was wir über Long Covid wissen

Vor einem Jahr wurde die Corona-Pandemie in Deutschland für beendet erklärt - manche aber leiden noch immer an den Folgen einer Infektion: Long Covid. Wie ist der Stand der Forschung? Von Ulrike Till und Ralf Kölbel.

tagesschau.de
Show threadLorraineJan 17, 2024

The great thing about high profile moron “experts” making blithe uninformed comments such as “Covid doesn’t really damage the immune system” is it angers people who ACTUALLY know & they come at them with #CovidPapers #Jha

This will be my continuing🧵on anything related to the destruction of #tcells #bcells #ImmuneDysregulation in an attempt to be organized if only for myself🖤

Published January 14, 2022
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02228-6

In truth just skimmed but my grasp on this in January 2024 is something that would have been impossible for me to understand in 2022 while experiencing my #sarscov2 2nd infection b/c my level of biology was zero & my lack of understanding led me to believe #hybridImmunity would give me 2 years at least. Mind you I never took my mask off except w/my MIL🦃🎄2021

Philip Dettmer “immune” book along w/the incredibly intelligent🧠🧠🧠here🐘&🐦have been invaluable in at least allowing me to read & generally follow along

Basically this study tells me, stay down for 6 months minimum

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC Medicine

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms for many months after infection, a condition referred to as “long COVID”, post-acute sequelae of COVID-19 (PASC), post-acute COVID-19 syndrome, or post COVID-19 condition. However, despite the plethora of research on COVID-19, relatively little is known about the molecular underpinnings of these long-term effects. Methods We have undertaken an integrated analysis of immune responses in blood at a transcriptional, cellular, and serological level at 12, 16, and 24 weeks post-infection (wpi) in 69 patients recovering from mild, moderate, severe, or critical COVID-19 in comparison to healthy uninfected controls. Twenty-one of these patients were referred to a long COVID clinic and > 50% reported ongoing symptoms more than 6 months post-infection. Results Anti-Spike and anti-RBD IgG responses were largely stable up to 24 wpi and correlated with disease severity. Deep immunophenotyping revealed significant differences in multiple innate (NK cells, LD neutrophils, CXCR3+ monocytes) and adaptive immune populations (T helper, T follicular helper, and regulatory T cells) in convalescent individuals compared to healthy controls, which were most strongly evident at 12 and 16 wpi. RNA sequencing revealed significant perturbations to gene expression in COVID-19 convalescents until at least 6 months post-infection. We also uncovered significant differences in the transcriptome at 24 wpi of convalescents who were referred to a long COVID clinic compared to those who were not. Conclusions Variation in the rate of recovery from infection at a cellular and transcriptional level may explain the persistence of symptoms associated with long COVID in some individuals.

BioMed Central
Show threadLorraineJan 11, 2024

@EeyoreTheCat @BlackAzizAnansi
HA!
HAAAAAAAAAAAAA!

This 2024 variant is equally as bad as 2022 & 2020 I can confidently report from the trenches☹️

Just b/c people have a broken #immuneSystem #ImmuneDysregulation #tCells #bCells from #constantCovid & aren’t displaying reactive symptoms indicative of a healthy immune system, the non-response “just a cold” isn’t the flex they think it is

https://www.science.org/doi/10.1126/sciadv.adg5461

BupuDec 29, 2023

My predictions for 2024:

- Ukraine-Russia war will come to an end with the US investing more in Israel, resulting in a loss of territory for #Ukraine but some stability at least.

- (because of above) #Ethiopia escalates violence in #Tigray and begins entry into #Eritrea to claim sea border in order to divest from #Djibouti.

- (also because of above) #Venezuela begins occupying #Guyana.

- Palestinians ejected from #Gaza and/or killed by #Israel and beginning of full-scale #genocide in #WestBank.

- US-Israel slowly start plan to drill for oil, build new port infrastructure and redevelop Gaza.

- #ClimateCrisis gets worse and ignored because of global conflicts.

- Global public health continues to diminish as COVID ruins immune systems globally bringing health care everywhere to a crisis point as millions more people develop potential lifelong disabilities from #LongCOVID

#War #Crisis #Decay #Capitalism #Fascism #ImmuneDysregulation #Immunocompromised #Russia #RussiaUkraineWar