Gurgaon-based Medanta Hospital Strengthens India’s Neurological Care Program with ‘Brain-Pacemaker surgery’

#AsianTalks #MedantaHospital #Gurugram #BrainPacemakerSurgery #DeepBrainStimulation #DBSTherapy #NeurologicalCare #Neuroscience #Neurosurgery #ParkinsonsDisease #Dystonia #EpilepsyCare #EssentialTremor #OCDTreatment #BrainHealth #NeuroInnovation #AdvancedHealthcare #AIinHealthcare

https://theasiantalks.com/gurgaon-based-medanta-hospital-strengthens-indias-neurological-care-program-with-brain-pacemaker-surgery/

"Six Myths and Misconceptions about Essential Tremor", Elan D. Louis (2024)
https://tremorjournal.org/articles/10.5334/tohm.948

"The myths are as follows: Myth 1: 'ET is not associated with a shorter life expectancy'. Myth 2: 'The pathophysiology of ET remains unclear'. Myth 3: 'There have also been studies that do not show any cerebellar degeneration'. Myth 4: 'ET is a postural or a kinetic tremor'. Myth 5: 'Action tremor in ET is usually bilateral and symmetric'. Myth 6: 'ET plus'"

#Neurology #EssentialTremor

Hantao Wang will defend his PhD dissertation on Tues 8/19 (10 am PDT), open to all via Zoom!

"Examining Cortical and Subcortical Processes Underlying Speech Auditory-motor Adaptation and Syllable Sequence Learning"

https://washington.zoom.us/j/94491363101?pwd=NGjWWgAy9SjuVM8eKCbPmeiDvxGiI2.1

#Speech #MotorControl #Parkinsons #EssentialTremor #DBS #Subcortical #Adaptation

Often amused at how much worse my essential tremor gets after I use vibrating power tools. I did 10 minutes of electric hedgetrimming, about the absolute max my M.E. will allow for in a day, and now i can barely hold a glass of water with two hands.
Bzzzzzzzzzzzz. That being said, I really love trimming hedges and I miss it a lot so it was worth it. Just might take me 2-3 weeks to finish our hedge at my pace.

#gardening #mecfs #essentialTremor

Researchers seem to be closer to pinpointing the causes of essential tremor. This recent (2024) huge genome-wide association study https://www.nature.com/articles/s42003-024-06207-4 implicates CA3 and CPLX1, supports GABA dysregulation theories, and highlights differences in Rho GTPase cycle.

Since Rho GTPases are involved in axon "growth, guidance, and branching" https://pmc.ncbi.nlm.nih.gov/articles/PMC2828272/, the last point helps explain the pathophysiology in ET: degeneration and swelling (formation of "torpedoes") of the axons, and dendrite loss/reduction in complexity of branching https://pmc.ncbi.nlm.nih.gov/articles/PMC10461794/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4240305/

Axon guidance processes were also implicated in this 2019 RNA-seq and GSEA study https://pmc.ncbi.nlm.nih.gov/articles/PMC7593093/, along with "microtubule motor activity," "endoplasmic reticulum (ER) to Golgi transport" and "calcium signaling/synaptic transmission."

Both the big GWAS study and this preprint published around the same time last year https://www.biorxiv.org/content/10.1101/2024.05.22.595233v1 found an association with BACE2, but the latter explains how that brings oligodendrocytes into the picture. The Rho GTPase PMC paper above has a section called "Other Guidance Cues" that describes how oligodendrocytes are involved in axon guidance.

This is clearly a complex network of processes, and that might explain why ET has so many different inheritance patterns: studies of smaller groups of related people often show different significant genes. Different changes at different key nodes in the network can cause similar cascading failures. Also, the common pathways might help explain what's happening in acquired ET, where pathology can be induced by things like lead and harmane https://pmc.ncbi.nlm.nih.gov/articles/PMC3073713/ (and other papers from the Elan Louis lab https://labs.utsouthwestern.edu/louis-lab/research#230548828-2207731419)

#EssentialTremor #Tremor #Etiology #Pathology #Pathophysiology #Neuroscience #Neurology

Does anybody know any good accessibility keyboards/mouse for people with Essential Tremors? The tremors are not super severe but the person that needs it can't use a regular keyboard.

#accesibility #essentialtremors #essentialtremor #disability #aid

@axoaxonic

Holly,

A friend just linked me to the "Essential3" Ulixacaltamide study. You had mentioned the earlier phases in Nov 2023. I did the "qualification" test online and they said I fit. But when I go to the appointment page to setup an intake call, it says "No times available in February" and won't let me advance to March. Or provide any other contact route.

Searching the web for the Praxis company, it is all about other test failures and the stock price tanking from $20 to $1.

https://www.biopharmadive.com/news/praxis-tremor-trial-results/644117/
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Despite study setback, a biotech plans to push tremor drug into late-stage testing

The trial found the drug was no better than a placebo at improving patients’ condition, as measured by a scorecard used to evaluate the severity of their tremors as well as how they perform daily activities like speaking, writing and standing. However, Praxis said its drug showed small, but statistically significant improvements over placebo on three other scorecards that served as secondary goals of the study.
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The current Phase 3:
https://www.mdsabstracts.org/abstract/essential3-an-innovative-multi-study-phase-3-program-to-evaluate-the-efficacy-and-safety-of-ulixacaltamide/

The intake page:
https://essential3study.com/

Do I even want to be part of this? And maybe get a placebo while wasting lots of time with their representatives? If they will even bother coming out to my very rural location... When their results depend on silly questions about self perception, that disagree with each other?

#essentialTremor #tremor

3/3 With SMwI, doctors have a powerful tool to accurately diagnose Parkinson's disease and essential tremor. This means better treatment and a higher quality of life for patients. #Parkinsons #EssentialTremor #MedicalBreakthrough

Read more: https://curedigest.com/science-news/parkinsons/susceptibility-map-weighted-mri-can-distinguish-tremor-dominant-parkinson-s-disease-from-essential-tremor-scientific-reports