For pre-meeting prep take a look at our Michigan Congressional District 4 candidates websites. Sean McCann will be present to meet with us on Wednesday at the Allegan Library.

https://seanmccannforcongress.com/
https://www.diop4mi.com/

#Michigan
#westmichigan
#politics
#democracy
#Democrats
#CD4

Perforin is the substance T and NK cells use to drill into an infected cell and kill it. Selin and Gill’s studies suggest that ME/CFS and long-COVID patients’ T cells produce almost no perforin

https://www.healthrising.org/wp-content/uploads/2025/05/Perforin_Selin_Webinar_25.gif

[alt text: graphs of perforin in two classes of cell. The healthy controls are tall grey bars, compared to 1/10 to 1/3 as tall bars for Long COVID and ME/CFS groups.]

they also found

a huge increase in a distinct type of T-cell called double-positive T-cell (CD4+ CD8+) in people with ME/CFS and/or long COVID. Instead of being differentiated into the two usual major T-cell subsets CD4 (helper/regulatory) and CD8 (killer) T-cells, these hybrid T-cells look like both CD4 and CD8 T-cells at the same time.

Selin found that these cells increased 8-9 fold in ME/CFS and long-COVID patients.

which compensates in part for the lower perforin, but also led to

a “highly dysregulated” cytotoxic T-cell immune response [...] That suggested that the immune system was kind of flailing around, trying to come up with an answer.

from https://www.healthrising.org/blog/2025/05/15/t-cell-exhaustion-chronic-fatigue-long-covid/

#COVID #COVID19 #MECFS #LongCOVID #CovidIsNotOver #TCells #NKCells #CD8 #CD4

A #vaccine #platform targeting #lung-resident memory #CD4+ T-cells provides #protection against heterosubtypic #influenza infections in mice and #ferrets

Source: Nature Communications, AbstractLung tissue-resident memory T (TRM) cells induced by influenza vaccination are crucial for heterosubtypic immunity upon re-exposure to the influenza virus, enabling rapid and robust responses upon reactivation. To enhance the efficacy of influenza vaccines, we induce the…

https://etidioh.wordpress.com/2024/11/29/a-vaccine-platform-targeting-lung-resident-memory-cd4-t-cells-provides-protection-against-heterosubtypic-influenza-infections-in-mice-and-ferrets/