#fiber #WeightLoss #Butyrate #Ozempic

"Dietary fibers are the main source of energy for bacteria living in our guts, and yet less than 5 percent of people in the US consume the recommended 25–30 grams (0.9–1 ounce) of fiber a day.

To make up for this, fiber supplements and 'invisible fiber'-infused foods are growing in popularity. But fibers are extremely diverse, so which do we choose?

Some fibers, like oat beta-glucans and wheat dextrin, are water-soluble, meaning they are easily fermented by gut bacteria.

Others, like cellulose and resistant starch, are less soluble or insoluble, meaning they stick to other materials to form stool.

Until now, writes biomedical scientist Elizabeth Howard from UA and her colleagues, 'there is no study that has investigated the role of various fibers in one cohort.'

To make up for this, the current study tested several forms of fiber in one cohort of mice. Only beta-glucan was found to increase the number of Ileibacterium in the mouse intestine. Other studies on mice have linked this bacterium to weight loss.

Sure enough, long before the 10-week marker, mice fed beta-glucan showed reduced body weight and body fat content compared to mice fed other forms of fiber.

The findings align with another recent study by Duca, which fed barley flour, rich in beta-glucan, to rodents. Even though the rats continued eating just as much of their high-fat diet as before, their energy expenditure increased and they lost weight anyway.

A similar outcome was observed in mice fed beta-glucan in the new study. These animals also showed increased concentrations of butyrate in their guts, which is a metabolite made when microbes break down fiber.

Butyrate induces the release of glucagon-like peptide-1 (GLP-1), which is the natural protein that synthetic drugs like Ozempic mimic to stimulate insulin release."

https://www.sciencealert.com/a-type-of-fiber-may-have-weight-loss-benefits-similar-to-ozempic

Bacteria in the gut could be the key to diagnosing chronic conditions | The Independent
https://www.independent.co.uk/bulletin/news/gut-bacteria-chronic-fatigue-long-covid-b2795838.html
La recherche a révélé que les personnes souffrant de fatigue chronique présentaient des taux plus faibles de #butyrate, un acide gras bénéfique, et d'autres nutriments essentiels au métabolisme et à l'énergie.

#microbiome #gutbacteria

For the next step in dealing with allergenic reactions is to successfully have the body's gut microbiome produce an abundance of anti-allergenic molecules.

Researchers at the University of Chicago have used polymeric micelles containing anti-allergen butyrate to cause gut Clostridia that also makes it to proliferate, preventing anaphylactic shock in mice from peanuts.

#Allergies #Allergens #Butyrate #Clostridia #Mice #Microbiome #Microbiology #Science #Scicomm

https://www.nature.com/articles/s41551-022-00972-5