Felippe KatanAquela época do ano onde a cabeça da pessoa atópica descaralha forte
RhyothemisPhenotypic overlap between atopic dermatitis and autism [2021]
https://link.springer.com/article/10.1186/s12868-021-00645-0
#atopy #eczema #AtopicDermatitis #allergy #autism #immunology
Phenotypic overlap between atopic dermatitis and autism - BMC Neuroscience
Background Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are associated with atopic dermatitis (AD). Moreover, ASD prevalence increases further as AD severity worsens, though these disorders share no common causative mutations. We assessed here the link between these two disorders in the standard, valproic acid mouse model of ASD. In prior studies, there was no evidence of skin involvement, but we hypothesized that cutaneous involvement could be detected in experiments conducted in BALB/c mice. BALB/c is an albino, laboratory-bred strain of the house mouse and is among the most widely used inbred strains used in animal experimentation. Methods We performed our studies in valproic acid (VPA)-treated BALB/c hairless mice, a standard mouse model of ASD. Mid-trimester pregnant mice received a single intraperitoneal injection of either valproic acid sodium salt dissolved in saline or saline alone on embryonic day 12.5 and were housed individually until postnatal day 21. Only the brain and epidermis appeared to be affected, while other tissues remain unchanged. At various postnatal time points, brain, skin and blood samples were obtained for histology and for quantitation of tissue sphingolipid content and cytokine levels. Results AD-like changes in ceramide content occurred by day one postpartum in both VPA-treated mouse skin and brain. The temporal co-emergence of AD and ASD, and the AD phenotype-dependent increase in ASD prevalence correlated with early appearance of cytokine markers (i.e., interleukin [IL]-4, 5, and 13), as well as mast cells in skin and brain. The high levels of interferon (IFN)γ not only in skin, but also in brain likely account for a significant decline in esterified very-long-chain N-acyl fatty acids in brain ceramides, again mimicking known IFNγ-induced changes in AD. Conclusion Baseline involvement of both AD and ASD could reflect concurrent neuro- and epidermal toxicity, possibly because both epidermis and neural tissues originate from the embryonic neuroectoderm. These studies illuminate the shared susceptibility of the brain and epidermis to a known neurotoxin, suggesting that the atopic diathesis could be extended to include ASD.
Divine Skin and CosmetologyAtopic Dermatitis Treatment | Expert Care at Divine Skin Clinic
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#EczemaCare #AtopicDermatitis #DivineSkinClinic #SkinTreatment #DrPranshuMishra
Vanessa Lässig~ Atopische Dermatitis ~
Trockene Haut, Juckreiz, Rötung.
Ein nerviges Krankheitsbild, das schon im jungen Alter auftreten kann und meist ein Leben lang anhält.
Die Erkrankung ist vererbbar und ein Schub durch verschiedene Faktoren auslösbar.
Einige (mögliche) Ursachen sind bekannt, aber es besteht, sowohl in der Human- als auch der Tiermedizin, noch Forschungsbedarf (z.B. bei Neurodermitis).
Weitere Infos bei eurem (Haut-)Tierarzt oder in meinem Artikel auf dogondo.de 🤓
Grüße gehen raus an alle menschlichen und tierischen Leidensgenossen! 👋🏻 👩🏼👧🏼🧒🏼
#atopie #atopicdermatitis #atopischedermatitis #dermatologie #tierärztin #vetmedscience #forschung #haut #hautprobleme #hautproblemebeimhund #juckreiz #neurodermitis #dogondo #hund #juckreizbeimhund #genetik #genetic
Your HealthAtopic dermatitis: how to recognize and treat it?
#AtopicDermatitis #Eczema
#EczemaTreatment #SensitiveSkin
#SkinCareRoutine
https://health.harbouchanews.com/2021/07/atopic-dermatitis-how-to-recognize-and.html
#AtopicDermatitis #Eczema
#EczemaTreatment #SensitiveSkin
#SkinCareRoutine
https://health.harbouchanews.com/2021/07/atopic-dermatitis-how-to-recognize-and.html
cafepharmaJ&J scoops up another atopic dermatitis antibody in $1.25B Numab rights deal—Health and biotech startups now get the majority of US Series A funding — Clinical-stage cancer biotech Actuate latest to eye summer IPO --http://bit.ly/w28kSd #jnj #atopicdermatitis #eczema #funding #ipos #oncology #cancer #pharma #pharmanews #biotech #biopharma #biotechnology #cafepharma
Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
https://doi.org/10.3389/fmed.2023.1180596
Published online 2023 Jun 27
#eczema #Chronic KidneyDisease #CKD #kidney #AtopicDermatitis
Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
BackgroundA bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determine the bidirectional causal association between atopic dermatitis and CKD.MethodsIndependent genetic instruments associated with atopic dermatitis and CKD at the genome-wide significance level were chosen from corresponding meta-analyses of genome-wide association studies. Summary-level data for atopic dermatitis were obtained from the EAGLE Eczema consortium (30,047 cases and 40,835 controls) and FinnGen consortium (7,024 cases and 198,740 controls). Summary-level data for CKD were derived from CKDGen consortium (64,164 cases and 625,219 controls) and FinnGen consortium (3,902 cases and 212,841 controls). The inverse-variance weighted method was used in the main analysis and supplemented with three sensitivity analyses.ResultsGenetic predisposition to atopic dermatitis was associated with an increased risk of CKD. For a one-unit increase in the prevalence of atopic dermatitis, the odds ratio of CKD was 1.07 (95% confidence interval: 1.01–1.12). In the reverse Mendelian randomization analysis, the odds ratio of atopic dermatitis was 1.14 (95% confidence interval: 1.03–1.26) for a one-unit increase in the prevalence of CKD. The associations persisted in sensitivity analyses and no pleiotropy was detected.ConclusionThis Mendelia...
Poetry NewsBacteria on skin
Cause eczema's rapid growth
An unsettling sight
#staphylococcusaureus #eczema #atopicdermatitis #haiku #poetry
http://www.medicalnewstoday.com/articles/how-bacteria-can-colonize-skin-and-accelerate-eczema-growth
Osteoarthritis
Asthma and atopic skin
Why the two are linked?
Research seeks to explain;
Mystery unsolved
#osteoarthritis #asthma #atopicdermatitis #research #cinquain #poetry
nadin brzezinski@sonofsamwise no, he is not stinky. He gets a bath every day #SpecialNeeds #AtopicDermatitis. He is a good doggo