Javier Díaz-NidoJun 17, 2023

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health

https://www.nature.com/articles/s41591-023-02380-x

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease - Nature Medicine

Cross-sectional and longitudinal analyses of tau pathology in preclinical Alzheimer’s disease reveal that tau tangles accumulate as a function of amyloid-β burden only in individuals positive for an astrocyte reactivity biomarker.

Nature
EMBO Mol. MedicineMar 13, 2023

Head-to-head comparison between multiple #PlasmaBiomarkers and neuropathological measures of #AmyloidPlaques and #NeurofibrillaryTangles.

By G. Salvado, O. Hansson & colleagues at Lund University

🗞️ Read #openaccess: https://doi.org/10.15252/emmm.202217123

Phys.orgOct 4, 2022

Referenced link: https://medicalxpress.com/news/2022-10-decreased-proteins-amyloid-plaques-tied.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-10-decreased-proteins-amyloid-plaques-tied.html

Originally posted by Phys.org / @[email protected]: https://twitter.com/medical_xpress/status/1577376529562091537#m

RT by @physorg_com: Study: Decreased proteins, not #amyloidplaques, are tied to #Alzheimer'sdisease @UofCincy @IOSPress_STM https://content.iospress.com:443/articles/journal-of-alzheimers-disease/jad220808 https://medicalxpress.com/news/2022-10-decreased-proteins-amyloid-plaques-tied.html

Study: Decreased proteins, not amyloid plaques, are tied to Alzheimer's disease

New research from the University of Cincinnati bolsters a hypothesis that Alzheimer's disease is caused by a decline in levels of a specific protein, contrary to a prevailing theory that has been recently called into question.

Medical Xpress