Viroid-like ā€œobeliskā€ agents are widespread in the ocean and exceed the abundance of RNA viruses in the prokaryotic fraction.
#Viroids #Obelisks #HammerheadRibozyme #Metatranscriptomics #UncorrectedManuscript
https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf033/8042533
New forms of life discovered inside human bodies
They resemble what scientists call #viroids, which are infectious loops of #RNA known for their effects on plants. #Obelisks share certain traits with these plant pathogens, yet they appear in human-associated bacteria. Their discovery came about when researchers began analyzing massive #genetic libraries, searching for patterns that did not match any known organisms.
https://www.earth.com/news/scientists-find-new-forms-of-life-inside-humans-rna-carriers-obelisks/
New forms of life discovered inside human bodies

Researchers find obelisks, mysterious RNA molecules in human bacteria that challenge our understanding of viruses and microscopic life.

Earth.com

Nature of Viruses

#DNA, #Prion, #Virion, #Viroids, #Virus, #Virusoides #Virology Nature of viruses is unclear, because it is difficult to classify them with in the accepted framework of living or…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/04/30/nature-of-viruses/

Nature of Viruses

#DNA, #Prion, #Virion, #Viroids, #Virus, #Virusoides #Virology Nature of viruses is unclear, because it is difficult to classify them with in the accepted framework of living or…. Medical Microbiol…

Medical Microbiology & RDT Labs

The more you study #biology, the more you realize how complicated and weird the living world (and our living bodies) are.

Latest discovery is #RNA "obelisks": self-replicating strands of naked RNA that hijack RNA polymerase to make copies of themselves. Unlike RNA #viruses, they don't make a protein coat for themselves, but unlike plant #viroids, it looks like they might actually encode some proteins (likely to encourage RNApol to replicate their sequences).

These things are almost certainly a part of your personal biology, happily replicating themselves without you ever knowing. It's unclear what effects (if any) these things have on their hosts.

It's likely these are echoes of the origin of life, the primitive #RNAworld that predates #DNA and cellular life.

https://www.science.org/content/blog-post/what-s-obelisk-anyway

(Oh, and if you haven't discovered Derek Lowe yet -- welcome to his wonderful world! He's a treasure ... check out his "things I'll never work with" series for a good chuckle.)

A new virus-like entity has just been discovered – ā€˜obelisks’ explained

Your mouth and your gut is full of them. But we don’t know if they’re friend or foe.

The Conversation
Theodor O. Diener (1921–2023) - was a plant pathologist working at the U.S. Department of Agriculture, Agricultural Research Service, Beltsville, USA. He is best known for his discovery of #viroids in 1971, the smallest infectious agents, which still can cause serious #plant #diseases like the potato spindle-tuber disease - article summarizing his life and his research by Robert A. Owens and Ahmed Hadidi - https://doi.org/10.3390/v15091895
The Remarkable Legacy of Theodor O. Diener (1921–2023): Preeminent Plant Pathologist and the Discoverer of Viroids

Theodor (ā€œTedā€) Otto Diener, the discoverer of viroids, died on 28 March 2023 at his home in Beltsville, Maryland, USA [...]

MDPI

#HardScience

https://futurism.com/videos/watch-the-smallest-pathogens-on-earth/

#Watch: The #Smallest #Pathogens on #Earth
Potato spindle tuber disease wasn’t a life-or-death situation, but it led to the discovery of viroids.

#potato #spindle #tuber #viroids