#Origin, #pathogenicity, and #transmissibility of a #human isolated #influenza A(#H10N3) virus from #China, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2432364
Human isolated H10N3 also showed respiratory #droplet #transmissibility in #ferrets. Considering continuous circulation in avian populations and repeated transmission to humans, strengthened #surveillance of H10 subtype viruses in poultry should be put into effect.
#Influenza A(#H5N1) shedding in #air corresponds to #transmissibility in #mammals
Source: Nature Microbiology, AbstractAn increase in spillover events of highly pathogenic avian influenza A(H5N1) viruses to mammals suggests selection of viruses that transmit well in mammals. Here we use air-sampling devices to continuously sample infectious influenza viruses expelled by experimentally infected ferrets. The resulting quantitative virus shedding kinetics data resembled…
Dual #receptor-binding, #infectivity, and #transmissibility of an emerging #H2N2 low pathogenicity avian #influenza virus
Source: Nature Communications, AbstractThe 1957 H2N2 influenza pandemic virus has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in…
Source: Nature Communications, AbstractThe 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulatin…
#Pathogenicity and #transmissibility of #bovine #H5N1 #influenza virus, Nature: https://www.nature.com/articles/s41586-024-07766-6
Importantly, bovine HPAI H5N1 virus bound to #sialic acids expressed in #human upper #airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate #infection and #transmission in #mammals.
HPAI H5N1 virus isolated from infected cow milk is characterized in mice and ferrets, was inefficiently transmitted in ferrets, and bound to sialic acids expressed in human upper airways, showing features that may facilitate infection in mammals.
#Characterization of a #human #H3N8 #influenza virus https://pubmed.ncbi.nlm.nih.gov/38408394/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1fgJURi2yzLesFml6et0Bb6krzs_FrNIYgPYVFN50JPwVNFg9s&fc=None&ff=20240226201417&v=2.18.0.post9+e462414
-- INTERPRETATION: Our data demonstrate that reverse genetics-generated A/Henan/2022 virus is a low pathogenic influenza virus (of #avian influenza virus descent) with some #antigenic resemblance to older human #H3N2 viruses and limited respiratory #droplet #transmissibility in #ferrets.
This work was supported by the Japan Program for Infectious Diseases Research and Infrastructure (JP23wm0125002), and the Japan Initiative for World-leading Vaccine Research and Development Centers (JP233fa627001) from the Japan Agency for Medical Research and Development (AMED).