Mastodawn

🧪 Protein name confusion created antibody mix-up affecting hundreds of papers #senescence #Science www.science.org/content/arti...

Protein name confusion created...

Edelruth, PBS Passport Holder Jun 2

Another excellent essay from Shanaka Anslem Perera. No idea where he finds the time to be this prolific, at this depth, but I'm very glad that he does.

A theory on failure modes of longevity drug promises, and an argument for concentrating on living well rather than on living longer.

https://shanakaanslemperera.substack.com/p/the-counterfeit-clock

#ShanakaAnslemPerera
#Gerontology
#Senescence

The Counterfeit Clock

Why the first trillion-dollar longevity trade reduced events instead of reversing aging, and why 2026 exposed the distance between moving a number and changing a life

Shanaka Anslem Perera

Knowledge Zone May 21

#KnowledgeByte: Negligible #Senescence is a term that describes organisms that don't show signs of biological aging, such as reduced reproductive capability, functional decline, or increased death rates with age.

It can also be described as a similar term to biological #Immortality, which means that an organism isn't more likely to die as it gets older.

https://knowledgezone.co.in/posts/Animals-that-Defy-Aging-664c3b7f9c4ce129fae5d57c

Marine Predators Chizé Lab Apr 23

📃New paper in Ecology letters 🐦 by ‪Bertille Mohring et al.

Life-history trade-offs and #senescence in black-browed #albatrosses from Kerguelen and Bird Island

Black-browed #albatrosses breeding in more variable environments display slower life histories (slow, late-onset reproductive senescence) and greater among-individual variation in life-history strategies

https://doi.org/10.1111/ele.70384

#seabird #ecology #science

Scientific Frontline Mar 20

Cellular #senescence is a biological paradigm in which a unique subpopulation of cells permanently and irreversibly stops dividing but evades apoptosis (programmed cell death). Instead of dying off, these arrested "zombie cells" remain metabolically hyperactive and linger within mammalian tissues.
#WhatIs #MolecularBiology #CellBiology #Geroscience #Longevity #sflorg
https://www.sflorg.com/2026/03/wi03202601.html

What Is: Cellular Senescence

Cellular senescence is recognized as a fundamental driver of "inflammaging"—chronic, systemic inflammation associated with advanced age.

Eishi Noguchi Jan 19

#SilentSunday

Marcescence
…still holding on 😊
Not senescence in this case 🤔

#GetOutside #Hiking #Nature #Walking #Creek #Marcescence #Senescence #Aging #Meditation #Photography

David Ojcius Jan 18

Cellular #senescence as a therapeutic target for #aging intervention

https://www.sciencedirect.com/science/article/pii/S2319417026000041 #openaccess #longevity

DanStafford Jan 5

#mwgic #2026 #Aging #Longevity #Lifespan #Healthspan #Senescence

https://newatlas.com/medical/anti-aging-extracellular-vesicles-embryonic-stem-cells/

The key to the cure for aging may lie in extracellular vesicles

Senescence. It’s a beautiful-sounding word whose tones suggest it should be a perfume or an essential oil. But that’s not even close. Senescence is the loss of a cell’s power to divide and grow, thus causing deterioration. It’s aging, completely unavoidable, and a 100% guaranteed pathway to death.

New Atlas

DanStafford Dec 16

#mwgic #2025 #Aging #Longevity #Senescence #SenescentCells

https://www.sciencedaily.com/releases/2025/12/251213032625.htm

A grad student’s wild idea triggers a major aging breakthrough

Senescent “zombie” cells are linked to aging and multiple diseases, but spotting them in living tissue has been notoriously difficult. Researchers at Mayo Clinic have now taken an inventive leap by using aptamers—tiny, shape-shifting DNA molecules—to selectively tag these elusive cells. The project began as an offbeat conversation between two graduate students and quickly evolved into a collaborative, cross-lab effort that uncovered aptamers capable of binding to unique surface proteins on senescent cells.

ScienceDaily

Rhyothemis Dec 15

my reading for this evening -

Aging: a possible road toward gut microbiota pathoadaptation [2025]
https://pubmed.ncbi.nlm.nih.gov/40770832/

#aging #senescence #GutMicrobiome #pathoadaptation

Aging: a possible road toward gut microbiota pathoadaptation - PubMed

Laboratory-raised mice live approximately seven times longer and healthier lives compared to their wild counterparts, due to a standardized healthy diet and limited exposure to environmental stressors. Aging is associated with increased inflammation and microbial dysbiosis. Collectively, these influ …

PubMed