Low-pH-dependent RNA binding and oligomerization of SID-1 transmembrane family proteins: Implications for RNA transport

In C. elegans, the protein SID1 plays a crucial role in the systemic RNA interference process by facilitating the transport of exogenous double-stranded RNA into the cytoplasm. Previously, Chen-Yu Zhang's group has already demonstrated that intact plant miRNA found in dietary sources can be absorbed through the mammalian digestive system and mediate cross-kingdom gene regulation.