A small mouse study found that supplemental vitamin D reduced neuroinflammation and reduced cell death in the hippocampus and prefontal cortex of offspring of female mice who were given propofol (a general anaesthetic) during pregnancy.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0349784
#Science #Pregnancy #Anaesthesia #Propofol #VitaminD #BrainDamage
Vitamin D alleviates neurotoxicity induced by propofol anaesthesia in the offspring of mice
Background Maternal propofol can induce neurotoxicity in the developing brain. Vitamin D modulates neurotrophin and neuromediator synthesis, reduces neuroinflammation and neuroapoptosis. The present study examined whether vitamin D could mitigate maternal propofol induced neurotoxicity in the offspring. Method Twenty pregnant mice were randomly divided into four groups. During the pregnancy, the groups designated as D and PD were given intraperitoneal vitamin D, while the groups labelled as P and C received 1 ml of saline. On the 14th day of pregnancy, groups P and PD received 200 mg kg-1 of propofol intraperitoneally. Newborn mice from the aforementioned groups were included in the study. The hippocampus and the prefrontal cortex were examined by immunohistochemistry at two postnatal ages: 7 and 45 days (PN7 and PN45). A battery of behavioural assessments was conducted using open field and elevated plus maze tests to evaluate potential alterations at PN45. Results Vitamin D reduced the expression of inflammatory and apoptotic factors induced by propofol, such as TNF-α (group P versus group PD: 0.79 (0.76–0.81) versus 0.36 (0.34–0.39), %95 CI; p < 0.001), Bax (group P versus group PD: 0.72 (0.69–0.74) versus 0.52 (0.5–0.54), %95 CI; p < 0.001) in the hippocampus in PN7. The administration of vitamin D resulted in enhanced expression of anti-apoptotic and neuroprotective proteins, such as Bcl-2 (group P versus group PD: 0.3 (0.27–0.33) versus 0.55 (0.53–0.57), %95 CI; p < 0.001) in the hippocampus in PN7. These changes also occurred in the hippocampus in PN45 and the prefrontal cortex in PN7 and PN45. No significant differences were identified in the behavioural tests between the groups. Conclusion Vitamin D treatment during pregnancy could prevent neurotoxicity in the offspring of mice exposed to propofol.
'Massive overdose' of sedative led to man's cardiac arrest, brain injury at Winnipeg hospital: lawsuit
The Alberta government and the father of a man who suffered cardiac arrest and permanent brain damage after he was allegedly given a "massive overdose" of a potent sedative at a Winnipeg hospital two years ago are suing the facility, three medical providers and two Manitoba health authorities for ne...
https://www.cbc.ca/news/canada/manitoba/propofol-overdose-alberta-lawsuit-9.7144046?cmp=rssHello, I'm back after a Dosis what medics. apparently nowadays call Jack-Ex
#propofol #anaesthesiaHola, os comparto mi última entrada en #escriturasocial. Se llama #Propofol (antes se llamó Epílogo pero creo que Propofol es mejor nombre :), y habla del fin de una relación. Lo escribí hace tiempo y puedo decir que es uno de mis poemas favoritos. Gracias por leer!
#poesía #poetry #versos #epílogo #propofoldelosdomingos
https://escritura.social/migueldejuan/epilogo
Propofol
Te sigo viendo, aún sin quererlo en la retama, en la lavanda en las huellas de los últimos paseos del otoño En los mosaicos del Arqueólogic...
Ich hätte jetzt gerne ne Dosis
#Propofol. Alk mag ich so gar nicht mehr.
Wie Propofol bewusstlos macht
Im Normalfall balanciert das Gehirn seine Aktivität auf einem schmalen Grat der Erregbarkeit. Messungen zeigen nun, was geschieht, wenn ein gängiges Anästhetikum ins Spiel kommt.
Warum Propofol uns in Narkose versetzt
Einschläfernde Wirkung: Obwohl Narkosemittel wie Propofol seit langem bei Operationen verwendet werden, haben Neurologen erst jetzt herausgefunden, wie
“A team of MIT
#neuroscientists may have unlocked the answer in the case of
#propofol. Propofol has been commonly used since the 1980s to put and keep patients in a state of unconsciousness. The new research indicates that it works by interfering with a brain’s “dynamic stability”—a state where
#neurons can respond to input, but the brain is able to keep them from getting too excited. “
#anesthesia #anestodon https://appdot.net/@jgordon/112791570676638713Consciousness studies: Propofol produces unconsciousness by destabilizing sensory system feedback and this inducing a chaotic network collapse.
https://gizmodo.com/we-finally-know-how-general-anesthesia-knocks-you-out-2000473321
The reboot process should be interesting too.
#jgshare
#Propofol wirkt schon ziemlich "cool".
War jetzt das vierte Mal, dass ich eine
#Vollnarkose bekommen habe. Ich wäre allerdings auch ohne gut zufrieden.
https://www.andreas-edler.de/blog/2024/06/langsam-wieder-wach/#Vorsorge #AlterMann Langsam wieder wach
Das Propofol ist verflogen und ich bin wieder gerade auf den Beinen. Allerdings noch ziemlich müde und schlapp. Glaube, ich schlafe heute ganz gut ein. Samstagabend um 19:30 Uhr das letzte Mal was gegessen und den gestrigen Tag hauptsächlich auf …<p class="read-more"> <a class="more-link" href="https://www.andreas-edler.de/blog/2024/06/langsam-wieder-wach/"> <span class="screen-reader-text">Langsam wieder wach</span> Read More »</a></p>
Magenspiegelung so weit überlebt.
Propofol ist ja Crazy. Ich bin noch völlig düllülü 🫠🤪😵💫
#Arzttermin #Propofol
RDN
CBC Health
FlohEinstein
Miguel de Juan
Reinald Kirchner
stti23 
scinexx - das wissensmagazin
Auscandoc
Andreas
🇺🇦luc