Auscandoc“It’s probably#anesthesia’s fault.”#anestodon
“We found that neural dynamics were more unstable in unconsciousness compared with the awake state. Cortical trajectories mirrored predictions from destabilized linear systems. We mimicked the effect of propofol in simulated neural networks by increasing inhibitory tone. This in turn destabilized the networks, as observed in the neural data. Our results suggest that #anesthesia disrupts dynamical stability that is required for consciousness.” #anestodon https://www.cell.com/neuron/fulltext/S0896-6273(24)00446-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS089662732400446X%3Fshowall%3Dtrue
“The brain has to operate on this knife’s edge between excitability and chaos. It’s got to be excitable enough for its neurons to influence one another, but if it gets too excitable, it spins off into chaos,” said study author and MIT professor Earl K. Miller in the release. “Propofol seems to disrupt the mechanisms that keep the brain in that narrow operating range.” #anesthesia #anestodon
“We looked at a simple circuit model of interconnected neurons, and when we turned up inhibition in that, we saw a destabilization. So, one of the things we’re suggesting is that an increase in inhibition can generate instability, and that is subsequently tied to loss of consciousness,” #anesthesia #anestodon
“A team of MIT #neuroscientists may have unlocked the answer in the case of #propofol. Propofol has been commonly used since the 1980s to put and keep patients in a state of unconsciousness. The new research indicates that it works by interfering with a brain’s “dynamic stability”—a state where #neurons can respond to input, but the brain is able to keep them from getting too excited. “ #anesthesia #anestodon https://appdot.net/@jgordon/112791570676638713
John Gordon (@[email protected])
Consciousness studies: Propofol produces unconsciousness by destabilizing sensory system feedback and this inducing a chaotic network collapse. https://gizmodo.com/we-finally-know-how-general-anesthesia-knocks-you-out-2000473321 The reboot process should be interesting too. #jgshare
Stu MarshallHad a letter published in BJA today about the importance of design for cognitive aids, and how future guideline documents should report them.
https://www.bjanaesthesia.org.uk/article/S0007-0912(24)00006-0/fulltext
Free full text (time limited):
https://authors.elsevier.com/a/1iTiF1dCDupOy
#HumanFactors #anaesthesia #anesthesiology #anestodon #design
Really good discussion and worthwhile read on the state of consent for #anaesthesia in the UK by Matt Ainsworth and Tim Cook (and not just because they reference our editorial in the first sentence! 😂)
#anesthesia #Anaestodon #anestodon
https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.16053
A really good article from Sabastian Omenyo and Laura Duggan on why SGAs should not be used routinely for laparoscopic surgery.
Comments?!
https://www.apsf.org/article/con-supraglottic-airway-devices-safety-concerns-in-laparoscopic-surgery/
#anaesthesia #anesthesia #anaestodon #anestodon
Comments?!
https://www.apsf.org/article/con-supraglottic-airway-devices-safety-concerns-in-laparoscopic-surgery/
#anaesthesia #anesthesia #anaestodon #anestodon
CON: Supraglottic airway devices: Safety concerns in laparoscopic surgery
In 1986, Sir Archie Brain patented the Laryngeal Mask Airway (LMA©).1 Four decades later, supraglottic airway devices (SADs) have evolved to include esophageal ports (called second-generation devices) and changed angulation to facilitate tracheal intubation...
Anaesthetists/Anesthesiologists
When doing TIVA what is your usual practice?
#anaesthesia #anesthesiology #anestodon #Anaestodon
Comments below then I’ll tell you why I’m asking 😜
TCI with pump algorithm
Syringe driver w self calculated rate
Either of above + volatile
Show me the results
Poll ended at .