2,3-Bis(acetylmercaptomethyl)#quinoxaline (BAMMQ) is an #antiviralAgent which inhibits #poliovirus #RNASynthesis #inVitro and #inVivo and inhibits #humanHerpesvirus1 multiplication in vitro. It does not interfere with attachment, penetration or #DNASynthesis, but interrupts a late stage in virus assembly and/or maturation. BAMMQ was first identified as an antiviral agent in 1974, when it was shown to inhibit poliovirus growth by 99.8% or more at concentrations as low as 10−5 M. That same year.
Circulating vaccine-derived #poliovirus type 1 [#cVDPV1] - #Israel (#WHO D.O.N., August 20 '25)

Im Abwasser verschiedener deutscher Großstädte wurden Polioviren nachgewiesen. Expertïnnen gehen davon aus, dass bereits viele Menschen in Deutschland mit dem #Poliovirus infiziert sind, ohne es zu wissen. Warum wir gerade jetzt eine hohe Impfquote brauchen: @UlrikeGebhardt https://www.riffreporter.de/de/wissen/poliovirus-deutsches-abwasser-impfung-kinderlaehmung-risiko
Poliovirus im deutschen Abwasser – gibt es ein Risiko?

Wie sich Impfviren wieder zu gefährlichen Varianten entwickeln können und warum gerade jetzt eine hohe Impfquote wichtig ist: der Virologe Andreas Dotzauer im Gespräch.

RiffReporter
Circulating vaccine-derived #poliovirus type 2 (#cVDPV2) - #Papua New Guinea (#WHO D.O.N., May 20 '25), https://etidiohnew.blogspot.com/2025/05/circulating-vaccine-derived-poliovirus.html
Circulating vaccine-derived #poliovirus type 2 (#cVDPV2) - #Papua New Guinea (#WHO D.O.N., May 20 '25)

Humanitarian Situation Update #gaza by 🔵 OCHA FEB-25

🔹 Over 586,000 children under the age of 10 have been vaccinated for #poliovirus across Gaza, reaching 99 per cent of the target population since the campaign began on FEB-22

🔹 Six newborns reportedly died from the cold weather in Gaza city and Khan Younis: health officials

🔹 The scheduled release of 620 Palestinian detainees has been postponed by ISR authorities

📑 Full report (prime source) 👇🏽

https://www.ochaopt.org/content/humanitarian-situation-update-267-gaza-strip

Humanitarian Situation Update #267 | Gaza Strip | United Nations Office for the Coordination of Humanitarian Affairs - occupied Palestinian territory

Over 586,000 children under the age of 10 have been vaccinated for poliovirus across Gaza, reaching 99 per cent of the target population since the campaign began on 22 February.

United Nations Office for the Coordination of Humanitarian Affairs - occupied Palestinian territory
Day 4 for diseases to be aware of is Poliomyelitis. Pre-pandemic we were very close to global eradication of polio virus but given the disruption of vaccine distribution because of COVID-19, it has… | Scott Krugman | 38 comments

Day 4 for diseases to be aware of is Poliomyelitis. Pre-pandemic we were very close to global eradication of polio virus but given the disruption of vaccine distribution because of COVID-19, it has not gone away. And now that USAID has been decimated, we can anticipate increases in the disease – which ends up being 1 flight away from the US. If you talk with your grandparents, they will let you know how much fear parents had every summer about sending their children to public pools and risking paralytic polio and why they lined up for the original Salk vaccine in the 1950s. The March of Dimes was founded to care for all the children with limb difficulties resulting from polio. Many polio survivors are still out there and are worth talking to! Illness 4: Poliomyelitis Type of infection: Virus Transmissibility: Highly contagious through fecal-oral route Incubation period: 2-6 days for non-paralytic polio, 7-12 days for paralytic polio Clinical Presentation: Majority of infections are asymptomatic or mild non-specific viral symptoms like fever, nausea, vomiting, sore throat and abdominal pain. If progressing to paralytic disease after hematogenous spread to the central nervous system, lower extremities are most frequently involved and large muscle groups become weak. Can progress to thoracic spinal cord segments which can cause respiratory failure. Risk: 100-850 inapparent infections to 1 case of paralytic polio. Complications: Bulbar polio (involvement of cranial nerves leads to rapid respiratory depression), long-term paralysis, limb deformities, late-onset post-polio syndrome where the weakness returns years later Evaluation: Diagnosis by PCR NAAT, CSF will have viral meningitis picture with lymphocyte predominance Treatment: none Prevention: Inactivated Polio Vaccine used in US. In areas with wild-type virus circulating oral polio vaccine is still used. Vaccine adverse event: Oral polio vaccine can mutate, and cause vaccine induced poliomyelitis with a risk of 1 case per 750,000 doses distributed. Pictures of limb deformity and a child in an iron lung. | 38 comments on LinkedIn

In the wake of #poliovirus findings in several EU countries, we compiled what we could share about #wastewater #surveillance of poliovirus in participating member states.

https://www.eu-wish.eu/news

E.g. 67% (18/27 countries) reported WES for poliovirus and non-polio enterovirus.

News | EU-WISH