Nephrogenic DI: polyuria (>3 L/day), polydipsia, dehydration despite adequate ADH
Causes: lithium, demeclocycline, foscarnet, amphotericin B, genetic (AQP2/V2R), hypercalcemia, hypokalemia, renal disease
Pathophys: ADH present but ↓ signaling → ↓ AQP2 insertion → ↓ water reabsorption in collecting ducts
Dx: urine SG <1.010, ± hypernatremia, no concentration after water deprivation (central DI would fully concentrate with DDAVP)

#MetaAI #MiniMedSchool #ClinicalPearl #NotMedicalAdvice #MedEd

So I've heard from people I should wait on my COVID vaccine at this point because a new one comes out next month.

This is bad advice if you're overdue like I was.

The current bivalent vaccine will protect you. The new one comes out maybe in a month? And availability may be difficult for a couple of months after. You may be waiting a while.

Go ahead and get the jab if you need it.

#COVID #COVID19 #Vaccine #Booster #NotMedicalAdvice

Don't forget to hug your plushies when you're happy, not just when you're sad, so you associate plushie hugs with pleasant warmth and happys instead of only sads

#NotMedicalAdvice #TherapyHelpsToo