CellBioNews
PLOS BiologyThis study shows that repetitive stimulation of hippocampal #astrocytes induces #astrogliosis & release of the inflammatory mediator LCN2, triggering #neuroinflammation, inhibition of #NMDAR-related neuronal activity & cognitive impairment #PLOSBiology https://plos.io/3LiknWpLCN2
DrBob, π§ Mechanic#Brain on Fire!
Clinical Guideline on Evaluation and Treatment for Autoimmune Encephalitis
#AntiNMDAR Encephalitis Clinical Practice Guideline
Improving Time to Diagnosis, Treatment, and Hospital Length of Stay
βA clinical practice guideline (CPG) was created to standardize evaluation and treatment for patients with suspected anti-methyl-d-aspartate receptor (#NMDAR) #autoimmuneencephalitis (AE), the most common AE in children. The objective of this study was to evaluate the CPG effect on time to #diagnosis, #treatment, and hospital length of stay (LOS).β
Sorry for Paywall (#AAN Profit Center!)
#neurology
https://www.neurology.org/doi/full/10.1212/CPJ.0000000000200218
Anti-NMDAR #Encephalitis Clinical Practice Guideline: Improving Time to Diagnosis, Treatment, and Hospital Length of Stay
βA clinical practice guideline (CPG) was created to standardize evaluation and treatment for patients with suspected anti-methyl-d-aspartate receptor (#NMDAR) autoimmune encephalitis (AE), the most common AE in children. The objective of this study was to evaluate the CPG effect on time to diagnosis, treatment, and hospital length of stay (LOS).β
#Neurology #autoimmune #catatonia #schizophrenia #psychiatry #AntiMNDAR
https://www.neurology.org/doi/10.1212/CPJ.0000000000200218
katch wreck"In a passive transfer mouse model, NMDAR-CAAR T cells led to depletion of an anti-NMDAR B cell line and sustained reduction of autoantibody levels without notable off-target toxicity. Treatment of patients may reduce side effects, prevent relapses, and improve long-term prognosis. Our preclinical work paves the way for CAAR T cell phase I/II trials in #NMDAR #encephalitis and further autoantibody-mediated diseases."