Mastodawn

Giuseppe Michieli Jun 3, 2024

#USA, #Jamestown Canyon virus (#JCV) isolated in a #mosquitoes pool at the #Michigan Department of Health and Human Services Bureau of Laboratories (MDHHS BOL). These are the first infected mosquitos detected for 2024. More: https://www.michigan.gov/mdhhs/inside-mdhhs/newsroom/2024/06/03/2024-mosquito

Victor M. Corman Sep 15, 2023

Our most recent publication on #HepatitisE whole genome sequencing: We analysed a 40-year old camel HEV and found evidence for virus compartmentalization within the cns in humans with chronic #HEV infections.
#CharitéVirology #PEI #LaborBerlin #JCV #Zoonoses @ChariteBerlin

https://authors.elsevier.com/a/1hluf4xITSo9-K

Giuseppe Michieli Sep 5, 2023

Jamestown Canyon #virus {#JCV} is transmissible by #Aedes aegypti and is only moderately blocked by #Wolbachia co-infection https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011616 #arbovirus #bunyavirus #EIDs #mosquitoes #research #science

Jamestown Canyon virus is transmissible by Aedes aegypti and is only moderately blocked by Wolbachia co-infection

Author summary Jamestown Canyon virus (JCV), a newly emerging virus in North America, can result in disease spillover from wild mammals into human populations via the bite of infected mosquitoes. We show that the mosquito Aedes aegypti, known for transmitting many viral pathogens to humans globally, and whose distribution is creeping northward in the USA toward regions where JCV is present, is likely able to transmit the virus. Wolbachia is an endosymbiotic bacterium being released in wild mosquito populations of because it limits the replication of human viruses inside the mosquito, limiting their transmission to humans. We show that Wolbachia has a limited ability to control the replication of JCV, which is likely because Wolbachia-induced antiviral response is quite weak, and unique aspects of negative-sense virus biology make them less susceptible to blocking. Our findings suggest that JCV may serve as a comparative model to positive-sense viruses like dengue in dissecting the mechanism of Wolbachia-mediated virus blocking. It also warns that shifting mosquito distributions, as expected under a changing climate, could bring JCV and Aedes mosquitoes into greater contact, potentially increasing the incidence of JCV in humans.