StructBiolCommunicationsFeb 17
The highest resolution DNA-free TaXPD structure to date uniquely resolves loop 510–514 in the long-form, DNA-free TaXPD model #Helicases #Archaea https://doi.org/10.1107/S2053230X26000105
Amelia Cervera 🧬Aug 26, 2025

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions.

#HIV1 #HIV1Integration #Rloops #Integrase #Helicases #IntronBindingComplex

https://www.nature.com/articles/s41564-025-02089-2

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions - Nature Microbiology

R-loops formed by RNA hybridization to DNA template strand during transcription influence HIV-1 integration into the CD4+ T cell genome. The unwinding of R-loops by splicing helicase Aquarius facilitates integration into speckle-associated domains.

Nature
CellBioNewsFeb 9, 2024

How nearly identical #RNA #helicases drive '#mRNA export' via distinct #protein complex pathways.

#UAP56 #apo_AREX

https://phys.org/news/2024-02-identical-rna-helicases-mrna-export.html

How nearly identical RNA helicases drive 'mRNA export' via distinct protein complex pathways

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages. A vital step in protein-coding gene expression is messenger RNA (mRNA) export, which involves shuttling mature mRNAs from the cell's nucleus to the cytoplasm.

Phys.org
The EMBO JournalAug 22, 2023
How can #replication initiator ORC load replicative #helicases in condensed chromatin?
Structural and biochemical work by Franziska Bleichert and colleagues shows how ORCA recruits ORC to certain #histone marks, and also reorganizes local #chromatin structure
https://www.embopress.org/doi/full/10.15252/embj.2023114654