Amelia Cervera π§¬Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions.
#HIV1 #HIV1Integration #Rloops #Integrase #Helicases #IntronBindingComplex
Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions - Nature Microbiology
R-loops formed by RNA hybridization to DNA template strand during transcription influence HIV-1 integration into the CD4+ T cell genome. The unwinding of R-loops by splicing helicase Aquarius facilitates integration into speckle-associated domains.
Martin Reijns