PsyPostNov 3, 2024
Early life stress predicts negative emotionality and inflammation in alcohol use disorder https://www.psypost.org/early-life-stress-predicts-negative-emotionality-and-inflammation-in-alcohol-use-disorder/?utm_source=dlvr.it&utm_medium=mastodon #earlylifestress #negativeemotionality #inflammation #alcoholusedisorder #emotionaldistress
Early life stress predicts negative emotionality and inflammation in alcohol use disorder

Emotional distress and inflammation are more prominent in alcohol use disorder patients with a history of childhood stress, such as abuse or neglect, according to new research.

PsyPost
Danai RigaDec 22, 2022

This is a super cool study, from a female-only team! Go #WomenInSTEM!

#EarlyLifeStress #Arc #SocialDefeat #DREADDs #Engram

Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity | bioRxiv
https://www.biorxiv.org/content/10.1101/2022.12.21.521303v1

Show threadDr. CateDec 22, 2022
@biorxivpreprint Congrats to postdoc Julie-Anne Balouek on her latest manuscript! This is the first paper from only my lab which we are so proud to share for your holiday reading.
We find that neurons activated by #earlylifestress are preferentially *reactivated* by adult stress, particularly in NAc, and that quieting this hypersensitivity at a cellular level also ameliorates behavior #inmice
Dr. CateNov 20, 2022

The Peña Lab is HIRING! Currently seeking 1-2 #postdocs (molecular or #datascientists) for multiple funded projects to understand how #earlylifestress impacts #epigenetic regulation of brain development and behavior.

We use #singlecell and other #sequencing approaches, computational analyses, and test our hypotheses back in vivo by gene and epigenome editing, activity manipulations, and pharmacological approaches - and of course behavior #inmice.

More here --> www.PenaLab.org