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We’ve been diving into the mesmerising anatomical diversity and evolution of cerebellar folding across 56 mammalian species with @r3rt0 Nicolas Traut @AleAliSousa @sofievalk
https://www.biorxiv.org/content/10.1101/2022.12.30.522292v1
Check it out in a short tooting thread 🔽
Please share if you are in Chicago! 👇
Please RT. My graduate student Peter Salvino @[email protected] has been missing since last night. Last seen in Lincoln Park, Chicago. See below. Please get in touch if you have any info
🐦🔗: https://twitter.com/lucasmpinto/status/1604629202124300289
The Human Transcriptome Cell Atlas (HTCA) database provides a one-stop interactive query to single-cell transcriptomics, single-cell splicing variants, spatial transcriptomics, and single-cell ATAC-sequencing profiles of adult and fetal tissues. Online analysis tools are also provided.
The sexually dimorphic bed nucleus of the stria terminalis (BNST) is comprised of several distinct regions, some of which act as a hub for stress-induced changes in neural circuitry and behavior. In rodents, the anterodorsal BNST is especially affected by chronic exposure to stress, which results in alterations to the corticotropin-releasing factor (CRF)-signaling pathway, including CRF receptors and upstream regulators. Stress increases cellular excitability in BNST CRF+ neurons by potentiating miniature excitatory postsynaptic current (mEPSC) amplitude, altering the resting membrane potential, and diminishing M-currents (a voltage-gated K+ current that stabilizes membrane potential). Rodent anterodorsal and anterolateral BNST neurons are also critical regulators of behavior, including avoidance of aversive contexts and fear learning (especially that of sustained threats). These rodent behaviors are historically associated with anxiety. Furthermore, BNST is implicated in stress-related mood disorders, including anxiety and Post-Traumatic Stress Disorders in humans, and may be linked to sex differences found in mood disorders.
katja heuer
A.K. Friedman
bioRxiv
Talia Lerner
Ming 'Tommy' Tang
JamieLarsH
Michele Banks
Soragni:Lab