https://www.biorxiv.org/content/10.1101/2025.09.02.673661v1?rss=1 #Extracellular #Mechanical #Ecm
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X, is for #temperature & #pressure! Y for pressure only! Sasa, what if, how, in place of X, Y is used🤔?
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📂 What is Enterprise Content Management (ECM)?
It's a system that centralizes documents, automates workflows, enforces compliance, and boosts collaboration—helping teams stay organized, efficient, and secure.
🔗 https://www.writerinformation.com/enterprise-content-management-system
Mechanical loading drives structural and functional improvements in muscle and tendon, protecting against injury at their interface - the myotendinous junction (MTJ) - and within the tendon matrix. However, the early cellular and molecular events that initiate these adaptations in humans remain poorly understood. To investigate this, we applied single nucleus RNA sequencing and in situ hybridization to map the acute transcriptional response of the human muscle-tendon unit to a single bout of eccentric resistance exercise, with a focus on extracellular matrix (ECM) regulation. We identified four transcriptionally distinct fibroblast subtypes expressing key ECM components, including COL1A1 and DCN. Three of these subtypes were localized to tendon and responded to exercise: two were spatially restricted to the collagen fascicles or the MTJ, while the third, enriched in the interfascicular matrix (IFM), exhibited the strongest response. This IFM population, marked by PDGFRA, upregulated PRG4 and VCAN, ECM genes linked to tissue lubrication and resilience. In parallel, exercise induced dynamic ECM regulation in myonuclei, particularly in a distinct subset of type II myonuclei at the MTJ that expanded in number and robustly upregulated COL22A1, a collagen essential for MTJ integrity. Together, these findings uncover a spatially organized, cell type-specific program of ECM remodeling in response to mechanical load, offering new insight into the early molecular events of human muscle-tendon adaptation. ### Competing Interest Statement The authors have declared no competing interest. Lundbeck Foundation, https://ror.org/03hz8wd80, R1982015-207 Novo Nordisk Foundation, NNF23OC0086015, NNF21OC0067146 Wu Tsai Human Performance Alliance
We compile so much #ecurepair rubbish🤸♀️! If you have time to waste, #hakunamatata 👇
https://www.5021.tips/ujanja/ecucomponents
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Remember, whatever You, go practice immediately coz #HapaUjanjaTu #learneverything #jifunze #ujanja #electronicsrepair #ecurepairs #wiring #techskills #techtipsandtricks #5021tips #diytips #ECUProgramming #keyprogramming #lostkeys #sparekeys #autorepairtips #autorepair #umeme #electronicsrecycling #electroniccomponents #ecu #electroniccomponent #autoelectrical #ecm
Don't scare working on #ToyotaLandCruiser300 juu #HapaUjanjaTu 👇
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Don't scare working on #ToyotaLandCruiser300 juu #HapaUjanjaTu 👇
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Love, Love is an album by American jazz trombonist and composer Julian Priester Pepo Mtoto recorded in two sessions on June 28 and September 13, 1973 and released on ECM the following year.
Tyran Grillo wrote for ECM Reviews:
With a title like Love, Love, Julian Priester’s ECM debut could be nothing but a warm embrace, an abstract melodrama lifted from the pages of an epic story. Hot on the heels of Bennie Maupin’s The Jewel in the Lotus, this album gives us more than we might expect and electrifies like a Mwandishi joint sans Herbie Hancock. Between the groovy “Prologue” and brass-laden “Epilogue” lie three interconnected pieces in two 20-minute suites, each a head-nodding peregrination couched in the vibrant expanse that only an ensemble of this size can maintain...
https://ecmreviews.com/2010/11/07/love-love/
https://www.youtube.com/watch?v=PoB6vNE9CnQ&list=RDPoB6vNE9CnQ&start_radio=1
#JulianPriester #PatGleeson
#HadleyCaliman #BayeteUmbraZindiko
#NduguLeonChancler
#RonMcClure #BillConnors #ecm #analogSynths #ecmreviews
Lookout Farm is an album by American jazz saxophonist Dave Liebman recorded over two days in October 1973 and released on ECM—his debut for the label.
Tyran Grillo wrote for ECM Reviews:
Saxophonist, flutist, and all-around wunderkind Dave Liebman—who only last year received an NEA Jazz Masters lifetime achievement award for his tireless efforts in music and instruction—made his ECM debut with Lookout Farm, his first of only two albums for producer Manfred Eicher as leader (the other being the enthralling Drum Ode; he would also guest on Steve Swallow’s Home some six years later) and a trendsetter for fledgling improvisers seeking their voices in the seventies and beyond. Here, he is joined by a telepathic ensemble that includes regulars Richie Beirach and John Abercrombie, in addition to a pointed percussion section...
https://ecmreviews.com/2010/11/06/lookout-farm/
https://www.youtube.com/watch?v=Kgs1u_IgBck&list=RDKgs1u_IgBck&start_radio=1
#DaveLiebman #RichardBeirach
#JohnAbercrombie #ecm #ecmreviews #jazz