Ocular coloboma is a congenital eye defect that occurs when the optic fissure fails to close properly during early development. Recent research utilizing lab-grown, miniature human retinas—known as retinal organoids—has identified how mutations in a specific growth-controlling protein contribute to this condition.
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https://www.sflorg.com/2026/04/gen04132601.html
Lab-grown retina gives gene change clue to rare childhood eye condition

Coloboma arises when a structure in the developing eye, the optic fissure, fails to close properly and often co‑occurs with other tissue‑fusion proble