Chloramphenicol-resistant microorganisms
This category includes such types of microorganisms: strains of Pseudomonas aeruginosa serrations, Mycobacterium tuberculosis and other acid-resistant bacteria, pathogens of gas gangrene and other clostridia, protozoa, fungi, viruses.
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Why should chloramphenicol be avoided?
When prescribing levomycetin, two circumstances must be taken into account: Firstly, this antibiotic sometimes causes very serious complications, in particular from the hematopoietic organs, often ending in death.
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Physical and chemical properties of chloroamphenicol
This antibiotic is slightly soluble in water (1 part of chloramphenicol per 400 parts of water), but it is highly soluble in alcohol, pyridine, ethylene glycol and propylene glycol.
Solutions cannot be sterilized in a steam sterilizer (autoclave) due to the weakening of the antibacterial effect.
Introduction of chloramphenicol in organism
The antibiotic is used orally through the mouth, less often rectally, and also topically in the form of ointments or aqueous solutions (for example, eye drops). For parenteral administration, chloramphenicol succinate soluble is used. Ingested chloramphenicol is quickly and completely absorbed, mainly in the small intestine.
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