Unser Heft 11/2025 ist raus!
Titelthema: Kunst trifft Wissenschaft
Außerdem:
- Serien Premiere des Elfenbeinwurms❗
- Methoden Special #RNA-Sequenzierung
- #Tierversuchspolitik;
- Pathologie;
- Forschungsförderung;
- Sättigungspillen;
- t-RNA #Chaperone
- Thermostabile #Polymerasen;
- …
Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php
🏷. I intuitively felt UNSAFE on the streets. I thought I was Paranoid, at thymes. "Everybody looks at me, mama.. am I ugly?" Mama made sure, I only went outside on RARE moments and for a few minutes max. Never alone, only with her or her son.. he was my #Chaperone™. He walked FAST to get me back & forth.
●. I didn't do Schoolparties or Schooltrips, I said no to them. I went to one, and my brother picked me up within 20min
●. My mom never made me a Passport, and I never was on a Plane
Mutation solves a century-old mystery in #meiosis.
#crossover #arabidopsis #genomics #HSP40 #chaperone
https://phys.org/news/2024-03-mutation-century-mystery-meiosis.html
The surprisingly connected origins of "chaperone", "cap", and "head". https://youtube.com/shorts/-URin4fZSiY
#etymology #WordNerd #linguistics #HistoricalLinguistics #language #words #lingcomm #chaperone #cap #head
https://www.nature.com/articles/s41598-023-31104-x#article-info
"In this study, we identified several misfolded proteins that are substrates for alpha 2-macroglobulin (α2M), an extracellular #chaperone. We also established a lysosomal internalization assay for α2M, which revealed that α2M mediates the lysosomal degradation of #extracellular misfolded #proteins."
Proteostasis regulates protein folding and degradation; its maintenance is essential for resistance to stress and aging. The loss of proteostasis is associated with many age-related diseases. Within the cell, molecular chaperones facilitate the refolding of misfolded proteins into their bioactive forms, thus preventing undesirable interactions and aggregation. Although the mechanisms of intracellular protein degradation pathways for intracellular misfolded proteins have been extensively studied, the protein degradation pathway for extracellular proteins remain poorly understood. In this study, we identified several misfolded proteins that are substrates for alpha 2-macroglobulin (α2M), an extracellular chaperone. We also established a lysosomal internalization assay for α2M, which revealed that α2M mediates the lysosomal degradation of extracellular misfolded proteins. Comparative analyses of α2M and clusterin, another extracellular chaperone, indicated that α2M preferentially targets aggregation-prone proteins. Thus, we present the degradation pathway of α2M, which interacts with aggregation-prone proteins for lysosomal degradation via selective internalization.
A network of small RNAs regulates sporulation initiation in #Clostridioides difficile
Franziska Faber and colleagues use small RNA/target interaction mapping in the enteric pathogen C. difficile to reveal the first RNA #chaperone #Hfq-dependent RNA interactome in a gram-positive #bacterium
Julia Clement
Laborjournal
The Book (2nd Edition)
CellBioNews
The EMBO Journal
Alliterative/Endless Knot
katch wreck