RE: https://mastodon.social/@gutenberg_org/116096840859015826
I love this image by Camillo #Golgi of a dogβs #OlfactoryBulb from his "Sulla fina anatomia degli organi centrali del sistema nervoso" (1885)!
This article highlights how #reading engages and regulates the nervous system. Interesting read π
#Neuroscience π§ͺ
New #ISEPpapers! Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma https://rupress.org/jcb/article/224/12/e202312109/278366/Tepsin-and-AP4-mediate-transport-from-the-trans
#Toxoplasma #Protists #Parasites #Microbes #Golgi #Evolution
#H5 #subtype avian #influenza virus induces #Golgi apparatus #stress #response via TFE3 pathway to promote virus #replication https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012748
These findings highlight the crucial role of the TFE3 pathway in mediating GAS response during AIV infection, shedding light on its significance in viral replication.
Author summary Influenza virus infection is known to trigger the endoplasmic reticulum stress response, a critical cellular reaction. The Golgi apparatus, positioned downstream of the endoplasmic reticulum, plays a vital role in protein modification and trafficking. Our study demonstrated that avian influenza virus (AIV) infection indeed induced GAS, as evidenced by the swelling and fragmentation of the Golgi apparatus observed in A549 cells. Moreover, the TFE3 pathway was significantly activated in response to GAS during AIV infection, which facilitates viral replication by enhancing endosome acidification and promoting the transcription of glycosylation enzymes. Inhibition of the TFE3 pathway significantly impeded AIV replication and decreased viral pathogenicity, suggesting its potential as a broad-spectrum target for antiviral drug development. These findings provide the first evidence linking AIV replication with GAS response, thereby advancing our understanding of AIV replication mechanisms.
Rebuilding nerves π¨
Vibha highlights a #preprint from Alice Mortimer, Adam Reid and Raman Das on how Golgi compaction paves the way to neuron repair.
Check it out π
https://prelights.biologists.com/highlights/golgi-compaction-facilitates-microtubule-nucleation-to-drive-adult-vertebrate-peripheral-neuron-regeneration-v3
Early Career Seminar:
Dr. Nicola Stevenson from University of Bristol
TODAY Wednesday, 01 May, at 13.00 in T09/09 (CTU building).
The role of Golgi organising proteins in extracellular matrix composition and assembly
flypapers
Fabrizio Musacchio
ISEP
micronicle.org
Giuseppe Michieli
preLights
mechanochemistry