A network of small RNAs regulates sporulation initiation in #Clostridioides difficile
Franziska Faber and colleagues use small RNA/target interaction mapping in the enteric pathogen C. difficile to reveal the first RNA #chaperone #Hfq-dependent RNA interactome in a gram-positive #bacterium
Heterotypic phase separation of #Hfq is linked to its roles as an #RNA #chaperone:
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01777-6
How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basis
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding
The EMBO Journal
Vivek Mutalik