💊 Why do some medications unexpectedly harm the kidneys — and can single-cell data uncover the reason?

🔗 Cell-type specific single-cell signatures reveal nephrotoxic drug effects. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.012

📚 CSBJ: https://www.csbj.org/

#Nephrotoxicity #CellBiology #Cheminformatics #AcuteKidneyInjury #DrugDiscovery #SingleCellGenomics #DrugDevelopment #CellAtlas

The incredible complexity of the human brain

Cubic millimetre of brain mapped in spectacular detail
Google scientists have modelled a fragment of the human brain at nanoscale resolution, revealing cells with previously undiscovered features.
https://www.nature.com/articles/d41586-024-01387-9
https://news.ycombinator.com/item?id=40313193

* one cubic millimetre (one-millionth of a whole brain) contains roughly 57,000 cells & 150 million synapses (the connections between neurons)

#brain #neurobiology #imaging #neuroscience #CellAtlas

I'm excited to be at my first conference since I joined @PLOS last year:

The Conceptual Power of Single-Cell Biology

Fun fact: my friend and colleague Quincey Justman and I conceived of this conference when we were both at Cell Press, sometime in 2018.

I'll be tooting as often as I can, at #CSSingleCells23. Hope to attract some others to toot instead of using the MAGA plutocrat's toy.

#SingleCell
#genomics
#Transcriptomics
#CellAtlas
#CSSingleCells23

https://www.cell-symposia.com/conceptual-single-cells-2023/

"Multiple myeloma (MM) accounts for ~10% of all haematologic malignancies. Little is known about high intratumour heterogeneities in patients stratified by the Revised International Staging System (R-ISS). Herein, we constructed a single-cell transcriptome atlas to compare differential expression patterns among stages."

#MulipleMyeloma #Transcriptomics #CellAtlas #Elife

https://elifesciences.org/articles/75340