Cancer-related wasting of organs and muscles has been linked to two factors secreted by cancerous tumors that reduce the appetite for protein-rich food.. The study was conducted in fruit flies, but humans have equivalent signals.
Summary: https://medicalxpress.com/news/2026-04-protein-early-herald-cancer-cachexia.html
Original paper: https://www.nature.com/articles/s41467-026-70074-2

Not wanting to eat protein may be early herald of cancer cachexia
A majority of people with advanced cancers endure cachexia, a muscle-, fat-, and organ-wasting condition that is currently incurable and can be life-threatening. Detecting and intervening early can slow progression, but poor understanding of how cachexia first arises in the body makes it difficult for doctors to identify the warning signs of impending wasting other than an overall loss of appetite (anorexia).


