... Continue to: https://youtube.com/shorts/huIxcpSX-V4?si=PUoxRv1HnpCobYIX
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.
Cancer causes loss of muscle (cachexia) through the release of a protein, Activin-A, that causes leakiness and loss of blood vessels, even those far from the tumor.
Original paper: https://www.nature.com/articles/s43018-025-00975-6
Many cancer survivors struggle with muscle weakness, which can be so profound that they may have difficulties walking up a couple of flights of stairs or going shopping for groceries on their own.