Creatinine in blood: normal values (level) and causes of increase/decrease #creatinine #cachexia
... Continue to: https://youtube.com/shorts/huIxcpSX-V4?si=PUoxRv1HnpCobYIX
Creatinine in blood: normal values (level) and causes of increase/decrease #creatinine #cachexia
... Continue to: https://youtube.com/shorts/huIxcpSX-V4?si=JM5booz-d1DZewg7
Creatinine in blood: normal values (level) and causes of increase/decrease #creatinine #cachexia
... Continue to: https://youtube.com/shorts/huIxcpSX-V4?si=xMW0SMgUz_6vJOIC
#Tumor patients can lose muscle mass (cachexia) -> bad prognosis. Study looks at all RNAs in skeletal muscles of cancer patients. Finds 2 complex clusters with distinct RNA expression, 1 cluster with stronger cachexia. Progress but no simple explanation for #cachexia.
https://www.nature.com/articles/s41586-025-09502-0
Molecular subtypes of human skeletal muscle in cancer cachexia - Nature

Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.

Nature
Cancer Cachexia: Liver Identified as Driver of Body Wasting

Cancer causes loss of muscle (cachexia) through the release of a protein, Activin-A, that causes leakiness and loss of blood vessels, even those far from the tumor.

Summary: https://theconversation.com/muscle-weakness-in-cancer-survivors-may-be-caused-by-treatable-weakness-in-blood-vessels-new-research-259765

Original paper: https://www.nature.com/articles/s43018-025-00975-6

#Science #Cancer #MuscleWasting #Cachexia

Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels – new research

Many cancer survivors struggle with muscle weakness, which can be so profound that they may have difficulties walking up a couple of flights of stairs or going shopping for groceries on their own.

The Conversation
Keto diet in cancer: A double-edged sword?

The ketogenic diet—on its own—may accelerate cachexia, a disease that leads to weight loss and muscle wasting, in cancer patients, a mice study finds.

Medical News Today
Our team @[email protected] is looking for a Clinically trained Research Fellow, with an interest in #oncology, #endocrinology or #metabolism, to study the drivers of #cancer #cachexia. Apply here 👇closing date Jan 6 2023. Please RT https://www.jobs.cam.ac.uk/job/38617/
Clinical Research Fellow (Fixed Term) - Job Opportunities - University of Cambridge

Clinical Research Fellow (Fixed Term) in the Department of Clinical Biochemistry at the University of Cambridge.