Daniel Hoffmann 🌼#Tumor patients can lose muscle mass (cachexia) -> bad prognosis. Study looks at all RNAs in skeletal muscles of cancer patients. Finds 2 complex clusters with distinct RNA expression, 1 cluster with stronger cachexia. Progress but no simple explanation for #cachexia.
https://www.nature.com/articles/s41586-025-09502-0
https://www.nature.com/articles/s41586-025-09502-0
Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.