🤯250 STED frames at 0.5 Hz with no bleaching and no phototoxicity!

Watch these HeLa cells stained with PKmito ORANGE, imaged by STED with a very short pixel dwell time and AI denoised.

Jaw breaking!

find out more in this cool manuscript : https://biorxiv.org/content/10.1101/2023.01.26.525571v1

#PKmito

Have a good #FluorescenceFriday with this live HeLa cell imaged by #STED. Actin in white and mitochondria in "Duo Intense Yellow" LUT by James Manton.

🙏 Image Credit: Tianyan Liu

#PKmito #SPYprobes #imaging #lifesciences

📢New product launch!
We introduce SpyRho 555 from the lab of Murat Sunbul in Heidelberg. SpyRho 555 is a fluorogenic dye binding to RhoBAST aptamer for live or fixed cell RNA imaging. It works for widefield, confocal, SIM, STED and PAINT-like SMLM.

SpyRho 555 product page: https://spirochrome.com/product/spyrho/

SpyRho BioRxiv preprint link: https://www.biorxiv.org/content/10.1101/2022.10.24.513449v1

We thank Daniel Englert and
Murat Sunbul for providing the images and the helpful discussions.

#SPYprobes #STED #imaging #RNA #LifeSciences

📢PKmito™ probes are available!
And to launch these in style, a 50% DISCOUNT on all PKmito™ products is available from our distributors network until March 31st 2023.
Don't miss your chance to try these outstanding mitochondrial probes.

Learn more about PKmito™ probes on our website: https://spirochrome.com

#PKmito #mitochondria #LifeSciences #imaging

We are very grateful to
Tianyan liu and the
@zhixingchen lab for these amazing tools and images.🙏

📢The amazing PKmito RED, ORANGE and DEEP RED probes will be available next Monday (Jan. 16th) from all our distributors!

We will announce a cool promotion for the launch of the probes. Make sure to follow us to be in the loop next Monday!

#PKmito #mitochondria #Imaging #lifesciences #STED #microscopy

📢A new FastAct™ probe is available!
We proudly introduce SPY700-FastAct
https://spirochrome.com/product/spy700-fastact/
Our FastAct™ probes capture fast actin structures.

The movie shows 2 cell populations, stained separately with our SPY-DNA probes, that were subsequently mixed together and further stained with SPY700-FastAct, allowing to track the 2 populations based on the color of the nuclei.

We are extremely grateful to Maxime Cammeraat from the Margadant lab in, Amsterdam for providing the raw images.

Last #FluorescenceFriday of the 2022 !

Let's have a look a this beautiful collective #CellMigration with a staining of the organelles and actin cytoskeleton.

(Hey @Spirochrome you know how to make probes, huh neat staining with FastAct)
#scicomm @cellcommlab @focalplane_jcs