π° "Multiscale order, flocking and phenotypic hysteresis in the cellular Potts model of epithelia"
https://arxiv.org/abs/2605.15159 #Physics.Bio-Ph
#Cond-Mat.Soft
#CellMigration #Cell
Multiscale order, flocking and phenotypic hysteresis in the cellular Potts model of epithelia
In epithelia, how do collective cell migration and tissue spatial organization feedback on each other? We address this question through large-scale numerical simulations of the cellular Potts model. By accounting for both cell morphology and cytoskeletal activity, we uncover a remarkably rich phase diagram featuring multiple types of orientational order, either as distinct phases or coexisting across length scales. We identify a specific pathway in parameter space along which a gradual increase in the actin polymerization rate drives a phase transition into a long-range flocking state. Simultaneously, quasi-long-range nematic order emerges at length scales much larger than the cell size due to the combined effects of directed motion and lateral cell-cell interactions. At length scales comparible to cell size, however, cells adopt an approximatively hexagonal morphology, resulting in hexanematic order, similar to that observed in reconstituted Madin-Darby Canine Kidney (MDCK) cell monolayers. With further increases in actin polymerization, nematic order becomes fully long-range, while hexatic order remains quasi-long-range and confined to short length scales, but independent of cytoskeletal activity. When noise is sufficiently low to allow crystallization at finite actin polymerization rate, cycling the cell-monolayer across the melting transition yields an example of phenotypical hysteresis, reminiscent of that observed across the epithelial-mesenchymal transition.
Frontiers | Decoding Rho GTPase signalling networks in directed cell migration
Small G proteins are molecular switches in the realm of cell biology, switching from the GTP-bound active form to the GDP-bound inactive form. They participa...
Frontiers | Editorial: Cell migration and tissue remodeling in infectious diseases
Pathogens are responsible for severe diseases that result in significant morbidity and mortality worldwide. During the pathogenesis of infectious diseases, c...
π° "The basement membrane determines the choice of wound healing mechanism across wound scales in the basal eukaryote Clytia hemiphaerica"
https://doi.org/doi:10.1091/mbc.E26-02-0094https://pubmed.ncbi.nlm.nih.gov/42126955/ #CellMigration #Cellπ° "AP-1-Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways"
https://doi.org/doi:10.1111/jcmm.71178https://pubmed.ncbi.nlm.nih.gov/42121345/ #CellMigration #Cellπ° "Tumor Protein D54 (TPD54) regulates intracellular protein trafficking, cellular function and disease progression in melanoma"
https://www.biorxiv.org/content/10.64898/2026.05.07.721771v1?rss=1 #CellMigration #Cellπ° "Bioelectric ink bridge: An electroactive casein bioink for cartilage regeneration by actively restoring the electrophysiological niche"
https://doi.org/doi:10.1016/j.biomaterials.2026.124289https://pubmed.ncbi.nlm.nih.gov/42114266/ #CellMigration #Cellπ° "Quantitative analysis of fibroblast migration reveals migratory states characterized by force generation, cell shape and motion"
https://www.biorxiv.org/content/10.64898/2026.05.06.723282v1?rss=1 #CellMigration #Force #Cellπ° "Evaluation of the effects of different irrigation activation techniques on the surface roughness of dentin and blood clot in regenerative endodontic models"
https://doi.org/doi:10.1007/s10103-026-04884-7https://pubmed.ncbi.nlm.nih.gov/42113054/ #CellMigration #Cell
Evaluation of the effects of different irrigation activation techniques on the surface roughness of dentin and blood clot in regenerative endodontic models - Lasers in Medical Science
Regenerative endodontic treatment (RET) is a biologically based approach aiming to restore the pulpβdentin complex in immature permanent teeth with necrotic pulps. In this procedure, a blood clot is induced within the canal to serve as a scaffold supporting stem cell migration, and its stability and regenerative success are closely linked to dentin surface morphology. This study focused exclusively on the quantitative assessment of surface roughness, without evaluating biological outcomes such as cellular response or long-term clot stability, and aimed to evaluate the effects of 17% EDTA activated by conventional needle irrigation (CNI), passive ultrasonic irrigation (PUI), EDDY, and SWEEPS on dentin and blood clot surface roughness using widefield confocal microscopy (CM). Seventy-five single-rooted maxillary incisors were decoronated and standardized to 11βΒ±β1 mm root length. Following instrumentation with VDW Reciproc R40 files and apical enlargement to 1.3 mm using Gates Glidden drills, canals received 20 mL of 17% EDTA for 5 min. In the activated groups, 1.5 mL EDTA was activated for 1 min, whereas the control group was irrigated with 20 mL saline. Specimens were split, and Sa values were measured on dentin and post-blood-clot surfaces using widefield CM. No significant differences were observed between canal regions for any technique regarding dentin and clot surface roughness (pβ>β.05). SWEEPS and EDDY produced higher Sa values on dentin surfaces than CNI in middle and apical regions (pβ<β.05). After blood application, the control group showed significantly higher Sa values, especially apically (pβ<β.05). Activation of EDTA using PUI, EDDY, or SWEEPS enhanced dentin surface roughness, which may influence clot adhesion and stability in RET.
Rxiv mechanobio