Kanold lab

@[email protected]
346 Followers
73 Following
21 Posts

Professor; Neuroscientist & Engineer @Jhu; JHU BME Phd Program Co-Director;
studying how we hear & how experience shapes the brain;
ultra runner (ideally trails); motorcycles;
views are my own.

#neuroscience
#auditory
#auditoryneuroscience
#hearing
#crossmodal
#cortex
#bme
#jhu
#jhubme
#science

webhttp://www.kanold.org
twitter@kanoldlab
Kanold labNov 16, 2024
New paper out: Our prior work had shown that adult visual deprivation can change circuits in the auditory cortex. Now Peter shows that temporary visual deprivation in adults can improve functional hearing and even attenuate age related high-frequency hearing loss: https://www.cell.com/iscience/fulltext/S2589-0042(24)02161-8
Kanold labJun 20, 2024

New preprint that was a long time in the making: HiJee and Travis use in vivo holographic optogenetic stimulation to look at how ensembles in auditory cortex interact:
https://www.biorxiv.org/content/10.1101/2024.06.17.599418v1

#neuroscience
#auditorycortex
#optogenetics
#Hearing
#persistance

Kanold labMay 7, 2024
New paper: Mingxuan built an automatic headfixation and imaging system and studied the changing responses and connectivity in auditory cortex during learning.
#neuroscience
#auditorycortex
#learning
#Hearing
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00500-X
Kanold labMay 2, 2024

Fun to contribute to a collaborative paper with Xiaoyin Chen (Allen Institute), Jesse Gillis (Toronto), Stephan Fisher (Inst. Pasteur), and Tony Zador (CSHL).  Using BARseq over the whole cortex, we show that visual loss shifts the cell-type compositional profiles of visual areas towards neighboring cortical areas within the same module. Thus, peripheral inputs sharpen the transcriptomic identities of areas within cortical modules.

https://www.nature.com/articles/s41586-024-07221-6

Whole-cortex in situ sequencing reveals input-dependent area identity - Nature

BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.

Nature
Kanold labMar 5, 2024

New paper out: Subplate neurons are very important for development, but seem to form a heterogenous cell population. Here Minzi shows that the sub-populations of subplate neurons vary between primary sensory areas pointing to a specialization of subplate and suggesting that different populations of subplate neurons might contribute differently to the development of individual sensory circuits.
#Cortex
#development
#neuroscience
#auditorycortex
#JHU

https://onlinelibrary.wiley.com/doi/10.1002/cne.25594

Kanold labFeb 29, 2024

New results out: Zac & Kelson looked at order and disorder in the functional representations in the auditory cortex. On large scales, there are tonotopic maps, but on small scales, neighboring cells can be tuned very differently. To reconcile this, they imaged 3D volumes and found that there is a fractured columnar small-world functional network organization.

#Hearing
#AuditoryCortex
#neuroscience
#jhu

Read here:

https://academic.oup.com/pnasnexus/article/3/2/pgae074/7606489

Fractured columnar small-world functional network organization in volumes of L2/3 of mouse auditory cortex

Abstract. The sensory cortices of the brain exhibit large-scale functional topographic organization, such as the tonotopic organization of the primary auditory

OUP Academic
Kanold labFeb 15, 2024

New paper out: Jonah trained mice on auditory tasks for >6 months and is able to postpone the detrimental effects of aging on hearing.
https://www.sciencedirect.com/science/article/pii/S0378595524000182

#Hearing #aging #AgingResearch #AuditoryCortex #neuroscience #jhu

Kanold labSep 17, 2023
New paper: Jonah shows that the Orbitofrontal cortex projections to A1 are functionally diverse and convey sound and task information:
https://www.cell.com/current-biology/pdf/S0960-9822(23)01139-9.pdf
Kanold labJul 18, 2023

New paper out: Georgia and Chih-Ting investigated the functional lateralization of auditory cortex. They built a bilateral microscope to simultaneously image both hemispheres in the same mouse. They find that the higher-order A2 shows functional lateralization and that A2 has lower and asymmetric hemispheric functional connections. Moreover, a lack of sound experiences prevents the development of asymmetric functional connectivity.

https://www.pnas.org/doi/10.1073/pnas.2219340120

#neuroscience
#hearing
#cortex

Kanold labFeb 23, 2023

New preprint: Didhiti shows that there is crossmodal plasticity in the pre-critical period. Early enucleation in mice leads to changes in the auditory cortex before ear opening.

https://www.biorxiv.org/content/10.1101/2023.02.21.529453v1

#neuroscience #crossmodal #blind #hearing #neuronewpaper #auditory #cortex